Quantification of Ventilation and Gas Uptake in Free-Breathing Mice With Hyperpolarized 129Xe MRI

Hyperpolarized 129 Xe magnetic resonance imaging is a powerful modality capable of assessing lung structure and function. While it has shown promise as a clinical tool for the longitudinal assessment of lung function, its utility as an investigative tool for animal models of pulmonary diseases is li...

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Bibliographic Details
Published in:IEEE transactions on medical imaging 2019-09, Vol.38 (9), p.2081-2091
Main Authors: Loza, Luis A., Kadlecek, Stephen J., Pourfathi, Mehrdad, Hamedani, Hooman, Duncan, Ian F., Ruppert, Kai, Rizi, Rahim R.
Format: Article
Language:English
Subjects:
Animal diseases
Animal models
Animals
Chemical equilibrium
free-breathing
gas exchange
Genetic algorithms
hyperpolarized
Image acquisition
Image resolution
Intubation
Longitude
Lung
Lung diseases
Magnetic resonance imaging
Mechanical ventilation
Medical imaging
MRI
NMR
Nuclear magnetic resonance
Organic chemistry
regional ventilation
Respiration
Respiratory function
Structure-function relationships
Ventilation
Xe-129
Xenon
Xenon 129
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Summary:Hyperpolarized 129 Xe magnetic resonance imaging is a powerful modality capable of assessing lung structure and function. While it has shown promise as a clinical tool for the longitudinal assessment of lung function, its utility as an investigative tool for animal models of pulmonary diseases is limited by the necessity of invasive intubation and mechanical ventilation procedures. In this paper, we overcame this limitation by developing a gas delivery system and implementing a set of imaging schemes to acquire high-resolution gas- and dissolved-phase images in free-breathing mice. Gradient echo pulse sequences were used to acquire both high- and low-resolution gas-phase images, and regional fractional ventilation was quantified by comparing signal buildup among low-resolution gas-phase images acquired at two flip-angles. Dissolved-phase images were acquired using both ultra-short echo time and chemical shift imaging sequences with discrete sets of flip-angle/repetition time combinations to visualize gas uptake and distribution throughout the body. Spectral features distinct to various anatomical regions were identified in images acquired using the latter sequence and were used for the quantification of gas arrival times for respective compartments.
ISSN:0278-0062
1558-254X
DOI:10.1109/TMI.2019.2911293