Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster

Confirmative diagnosis of SARS-CoV-2 infections has been challenged due to unsatisfactory positive rate of molecular assays. Here we identified a family cluster of SARS-CoV-2 infections, with five of six family members were SARS-CoV-2-specific immunoglobin serology testing positive, while molecular...

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Bibliographic Details
Published in:Emerging microbes & infections 2020-01, Vol.9 (1), p.924-927
Main Authors: Xu, Yan, Xiao, Meng, Liu, Xinchao, Xu, Shengyong, Du, Tiekuan, Xu, Jun, Yang, Qiwen, Xu, Yingchun, Han, Yang, Li, Taisheng, Zhu, Huadong, Wang, Mengzhao
Format: Article
Language:English
Subjects:
Adult
Betacoronavirus - genetics
Betacoronavirus - immunology
Betacoronavirus - isolation & purification
China
Clinical Laboratory Techniques - standards
Cluster Analysis
Coronavirus Infections - diagnosis
Coronavirus Infections - diagnostic imaging
Coronaviruses
COVID-19
COVID-19 Testing
Family
Female
Humans
Immunoglobulins - blood
Infections
Letter
Male
Middle Aged
Pandemics
Pneumonia, Viral - diagnostic imaging
Polymerase Chain Reaction - standards
SARS-CoV-2
Serologic Tests - standards
Serology
Severe acute respiratory syndrome coronavirus 2
Time Factors
Tomography, X-Ray Computed
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Summary:Confirmative diagnosis of SARS-CoV-2 infections has been challenged due to unsatisfactory positive rate of molecular assays. Here we identified a family cluster of SARS-CoV-2 infections, with five of six family members were SARS-CoV-2-specific immunoglobin serology testing positive, while molecular assays only detected two of this five patients even repeated twice. We comprehensively analyzed this familial cluster of cases based on the clinical characteristics, chest CT images, SARS-CoV-2 molecular detection results, and serology testing results. At last, two patients were diagnosed with COVID-19, two were suspected of COVID-19, and two were considered close contacts. Our results emphasized the significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections, especially for COVID-19 close contacts screening.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2020.1752610