Galectin-1 expression in oral squamous cell carcinoma: An immunohistochemical study

Context: Oral squamous cell carcinoma (OSCC) of the head and neck are a heterogeneous group of neoplasms with an increasing rate of mortality and morbidity. OSCCs are characterized by a high degree of local invasiveness and metastasis to cervical lymph nodes but show a lower rate of distant metastas...

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Published in:Journal of oral and maxillofacial pathology : JOMFP 2020-01, Vol.24 (1), p.186-186
Main Authors: Salunkhe, Vaibhavi, Mahajan, Aarti, Prakash, Nilima, Pradeep, G, Patil, Rekha, Gajdhar, Sajda
Format: Article
Language:English
Subjects:
Angiogenesis
Cancer
Cancer metastasis
Cancer research
Carcinoma
Cell adhesion & migration
Cell migration
Connective tissue
Extracellular matrix
Galectin-1
Immunohistochemistry
Invasiveness
Kruskal-Wallis test
Lectins
Lymph nodes
Lymphatic system
Medical prognosis
Metastases
Metastasis
Monoclonal antibodies
Morbidity
Mortality
Neoplasia
Oral cancer
Oral squamous cell carcinoma
Original
Polymers
Protein expression
Proteins
Squamous cell carcinoma
Statistical analysis
Statistics
Tumors
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Summary:Context: Oral squamous cell carcinoma (OSCC) of the head and neck are a heterogeneous group of neoplasms with an increasing rate of mortality and morbidity. OSCCs are characterized by a high degree of local invasiveness and metastasis to cervical lymph nodes but show a lower rate of distant metastasis. Galectin-1 (Gal-1), a β-galactoside-binding lectin, is known to regulate tumor cell growth, angiogenesis, mediate cell-cell or cell-extracellular matrix adhesion and promote cancer cell migration. Aims: This study aims to evaluate the Gal-1 expression in different clinical stages and histological grades of OSCC. Settings and Design: Forty histopathologically diagnosed cases of OSCC, including 16 cases of well-differentiated, 18 moderately differentiated and 6 poorly differentiated carcinomas, were included in the study group. Materials and Methods: The samples were subjected to staining using primary mouse monoclonal antibodies against Gal-1 and visualized using polymer-HRP detection system. Statistical Analysis: The nonparametric Mann-Whitney U-test and Kruskal-Wallis ANOVA test were used for the statistical analysis. Results: Gal-1 expression was higher in advanced stages of OSCC, and the results were statistically significant. Immunoexpression of Gal-1 increased with advancing histological grades of OSCC with statistically significant results. Conclusion: Gal-1 plays an important role in invasion, metastasis and as a prognostic marker.
ISSN:0973-029X
1998-393X
DOI:10.4103/jomfp.JOMFP_240_19