Anti-LRP4 Antibody-associated Myasthenia Gravis with a Rare Complication of Thymoma Successfully Treated by Thymectomy

We herein report the case of a 65-year-old woman diagnosed with myasthenia gravis (MG) after complaining of double vision. The patient had anti-low-density lipoprotein receptor-related protein 4 (LRP4) antibody in her serum, although antibodies against the acetylcholine receptor and muscle-specific...

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Bibliographic Details
Published in:Internal Medicine 2020/05/01, Vol.59(9), pp.1219-1222
Main Authors: Aoki, Sho, Nagashima, Kazuaki, Furuta, Minori, Makioka, Kouki, Fujita, Yukio, Saito, Kazuma, Kashima, Tomoyuki, Nakajima, Nozomi, Ikota, Hayato, Higuchi, Osamu, Ikeda, Yoshio
Format: Article
Language:English
Subjects:
anti-LRP4 antibody
Case Report
Computed tomography
endoscopic thymectomy
Internal medicine
Myasthenia
Myasthenia gravis
myasthenia gravis (MG)
Neuromuscular junctions
Positron emission tomography
Protein-tyrosine kinase
Receptor density
Thymectomy
Thymoma
Tomography
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Summary:We herein report the case of a 65-year-old woman diagnosed with myasthenia gravis (MG) after complaining of double vision. The patient had anti-low-density lipoprotein receptor-related protein 4 (LRP4) antibody in her serum, although antibodies against the acetylcholine receptor and muscle-specific tyrosine kinase were not detected. Chest computed tomography showed an anterior mediastinal tumor with a high uptake on fluorodeoxyglucose-positron emission tomography. Endoscopic thymectomy successfully ameliorated her ocular symptoms and showed the lesion to be thymoma. The present case revealed that anti-LRP4 antibody-associated MG can be associated with thymoma, which has been regarded as a rare complication of this disease thus far.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.3828-19