Caulis Sargentodoxae Prescription Plays a Therapeutic Role with Decreased Inflammatory Cytokines in Peritoneal Fluid in the Rat Endometriosis Model

Caulis Sargentodoxae prescription has been confirmed by the gynecological clinical observation to be effective in the treatment of endometriosis (EMs), and inflammatory cytokines were involved in EMs. In this paper, animal experiments were designed to explain anti-inflammatory mechanisms of Caulis S...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-9
Main Authors: Sun, Zhaogui, Niu, Yanan, Yu, Lin, Shi, Yan, Cao, Yang, Zhuang, Meng-fei, Zhang, Ting-ting
Format: Article
Language:English
Subjects:
Abdomen
Animal experimentation
Animal research
Anti-inflammatory drugs
Antibodies
Binding sites
Celecoxib
Chinese medicine
Cyclooxygenase-2
Cytokines
Drug dosages
Endometriosis
Endometrium
Enzyme-linked immunosorbent assay
Experiments
Health aspects
Immunohistochemistry
Infertility
Inflammation
Interleukin 1
Interleukin 2
Interleukin 6
Laboratory animals
Menstruation
mRNA
Oral administration
Ovariectomy
Ovaries
Peritoneal fluid
Peritoneum
Physiology
Polymerase chain reaction
Prostaglandin E2
Prostaglandin endoperoxide synthase
RNA
Transplantation
Tumor necrosis factor-α
Uterus
Western blotting
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Summary:Caulis Sargentodoxae prescription has been confirmed by the gynecological clinical observation to be effective in the treatment of endometriosis (EMs), and inflammatory cytokines were involved in EMs. In this paper, animal experiments were designed to explain anti-inflammatory mechanisms of Caulis Sargentodoxae prescription on endometriosis. The EMs model was established by autoplastic transplantation, and rats were randomly divided into seven groups: normal control group, model group, ovariectomized group, gestrinone (Western medicine) group, Caulis Sargentodoxae prescription (Chinese medicine) group, celecoxib (inhibitor) group, and combination (Chinese medicine + inhibitor) group. After oral administration for 21 days, the growth inhibitory rates of the ectopic endometria in treatment groups were evaluated, and the levels of inflammatory cytokines in the serum and peritoneal fluid were determined by ELISA, as well as the expression of prostaglandin endoperoxide synthase 2 (PTGS2) in the ectopic endometrial tissues was detected by real-time polymerase chain reaction, immunohistochemistry, and western blotting. The growth inhibitory rates of the ectopic endometria were significantly higher in the Caulis Sargentodoxae prescription group and gestrinone group, in comparison with the model group p
ISSN:1741-427X
1741-4288
DOI:10.1155/2020/9627907