The effects of exposure to fluoxetine during lactation on testicular tissue and sperm parameters in mice offspring

Fluoxetine is a selective serotonin reuptake inhibitor is commonly prescribed to treat maternal depression in pregnancy and lactation. This study aimed to investigate the effects of maternal exposure to fluoxetine via lactation on testicular tissue, sperm parameters including count, motility, viabil...

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Bibliographic Details
Published in:Veterinary research forum 2020, Vol.11 (1), p.35-42
Main Authors: Karimipour, Mojtaba, Ahmadi, Abbas, Javanmard, Masoumeh Zirak, Jafari, Abbas, Mohebi, Maryam, Hosseinalipour, Elnaz
Format: Article
Language:English
Subjects:
Animals
Antidepressants
Deoxyribonucleic acid
DNA
DNA damage
Drug dosages
Drug therapy
Embryos
Fluoxetine
Hormones
Hypothalamus
Infertility
Lactation
Male reproductive system
Mental depression
Morphology
Mothers
Motility
Original
Oxidative stress
Pregnancy
Serotonin
Sperm
Spermatogenesis
Studies
Testes
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Summary:Fluoxetine is a selective serotonin reuptake inhibitor is commonly prescribed to treat maternal depression in pregnancy and lactation. This study aimed to investigate the effects of maternal exposure to fluoxetine via lactation on testicular tissue, sperm parameters including count, motility, viability, and normal morphology and testicular oxidative stress status in male mice offspring. Ten mice dams were divided into control and experimental groups. The control group received water and the experimental group received fluoxetine (20.00 mg kg -1 ) by gavage daily from postnatal days of 0-21. Histology of testis, sperm parameters and oxidative stress in the testicular tissue were analyzed at 80 days after birth in their male offspring (n = 8). Significant reductions in the body and testes weights were observed in animals exposed to fluoxetine. Additionally, fluoxetine exposure significantly reduced all sperm parameters, tubular diameter and epithelial height of the seminiferous tubules as well as Leydig cells number. Significant increases in the testicular malondialdehyde levels and percentage of sperm with chromatin/DNA damage were observed in mice exposed to fluoxetine compared to control. These findings suggest that maternal exposure to fluoxetine during lactation in mice has a negative effect on the testicular tissue of their offspring and impairs the spermatogenesis process which in turn can induce infertility.
ISSN:2008-8140
2322-3618
DOI:10.30466/vrf.2018.82090.2082