Dietary intake from complementary feeding is associated with intestinal barrier function and environmental enteropathy in Brazilian children from the MAL-ED cohort study

• Published in: British journal of nutrition 2020-05, Vol.123 (9), p.1003-1012
• Main Authors: Costa, P N, Soares, A M, Filho, J Q, Junior, F S, Ambikapathi, R, Rogawski McQuade, E T, Guerrant, R L, Caulfield, L E, Lima, A A M, Maciel, B L L
• Format: Article
• Language: English
• Subjects: Adequacy; Biomarkers; Brazil - epidemiology; Breast Feeding; Breastfeeding & lactation; Caregivers; Children; Children & youth; Childrens health; Chronic illnesses; Cohort analysis; Cohort Studies; Data collection; Development projects; Diet; Diet - standards; Dietary intake; Energy intake; Enteritis - epidemiology; Enteritis - etiology; Etiology; Family income; Feeding; Female; Folic acid; Food; Food intake; Human and Clinical Nutrition; Humans; Immune system; Infant; Infant Nutritional Physiological Phenomena; Infants; Infections; Intestine; Intestines - physiology; Lactulose; Male; Malnutrition; Mannitol; Microbiota; Neopterin; Nutrients; Nutritional Status; Parent educational background; Peroxidase; Public health; Questionnaires; Ratios; Regression analysis; Regression models; Risk analysis; Risk factors; Sanitation; Thiamine
• ISSN: 0007-1145; 1475-2662; 1475-2662
• DOI: 10.1017/S0007114520000215

A child's diet contains nutrients and other substances that influence intestinal health. The present study aimed to evaluate the relations between complementary feeding, intestinal barrier function and environmental enteropathy (EE) in infants. Data from 233 children were obtained from the Brazilian site of the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project cohort study. Habitual dietary intake from complementary feeding was estimated using seven 24-h dietary recalls, from 9 to 15 months of age. Intestinal barrier function was assessed using the lactulose-mannitol test (L-M), and EE was determined as a composite measure using faecal biomarkers concentrations - α-1-antitrypsin, myeloperoxidase (MPO) and neopterin (NEO) at 15 months of age. The nutrient adequacies explored the associations between dietary intake and the intestinal biomarkers. Children showed adequate nutrient intakes (with the exception of fibre), impaired intestinal barrier function and intestinal inflammation. There was a negative correlation between energy adequacy and L-M (ρ = -0·19, P < 0·05) and between folate adequacy and NEO concentrations (ρ = -0·21, P < 0·01). In addition, there was a positive correlation between thiamine adequacy and MPO concentration (ρ = 0·22, P < 0·01) and between Ca adequacy and NEO concentration (ρ = 0·23; P < 0·01). Multiple linear regression models showed that energy intakes were inversely associated with intestinal barrier function (β = -0·19, P = 0·02), and fibre intake was inversely associated with the EE scores (β = -0·20, P = 0·04). Findings suggest that dietary intake from complementary feeding is associated with decreased intestinal barrier function and EE in children.