Antenatal corticosteroids and preterm offspring outcomes in hypertensive disorders of pregnancy: A Japanese cohort study

• Published in: Scientific reports 2020-06, Vol.10 (1), p.9312-9312, Article 9312
• Main Authors: Ushida, Takafumi, Kotani, Tomomi, Hayakawa, Masahiro, Hirakawa, Akihiro, Sadachi, Ryo, Nakamura, Noriyuki, Moriyama, Yoshinori, Imai, Kenji, Nakano-Kobayashi, Tomoko, Kikkawa, Fumitaka
• Format: Article
• Language: English
• Subjects: 692/700/1720/3185; 692/700/1720/3186; 692/700/1720/3187; Adrenal Cortex Hormones - therapeutic use; Adult; Birth Weight; Cerebral Intraventricular Hemorrhage - etiology; Cerebral Intraventricular Hemorrhage - mortality; Child, Preschool; Cohort analysis; Corticoids; Corticosteroids; Female; Gestation; Gestational Age; Health risk assessment; Hemorrhage; Humanities and Social Sciences; Humans; Hypertension; Hypertension, Pregnancy-Induced - drug therapy; Infant, Newborn; Infant, Small for Gestational Age; Intensive Care Units, Neonatal; Male; Maternal Age; multidisciplinary; Neonates; Offspring; Paralysis; Periventricular leukomalacia; Population studies; Pregnancy; Pregnancy Outcome; Premature Birth - prevention & control; Respiratory distress syndrome; Respiratory Distress Syndrome, Newborn - etiology; Respiratory Distress Syndrome, Newborn - mortality; Retrospective Studies; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-66242-z

To estimate whether antenatal corticosteroids (ACS) improve short- and long-term preterm offspring outcomes in singleton pregnancies complicated by hypertensive disorders of pregnancy (HDP) similar to pregnancies without HDP. This population-based retrospective study was conducted based on an analysis of data collected by the Neonatal Research Network of Japan on 21,014 singleton neonates weighing ≤1,500 g between 24 and 31 weeks’ gestation during 2003–2016. Logistic regression analyses were performed to compare short- and long-term offspring outcomes between mothers receiving ACS treatment and those who did not among pregnancies with HDP and without HDP. Of 21,014 neonates, 4,806 (22.9%) were born to mothers with HDP. ACS treatment was associated with significant decreases in short-term adverse outcomes in the both HDP and non-HDP groups, with similar reduced odds of neonatal death, respiratory distress syndrome, and intraventricular haemorrhage (IVH). However, ACS treatment did not significantly decrease severe IVH (aOR 0.76; 95% CI 0.51–1.13) and periventricular leukomalacia (1.14; 0.78–1.66) in the HDP group. In addition, ACS treatment in mothers without HDP significantly decreased cerebral palsy (aOR 0.70; 95% CI 0.58–084), developmental quotient scores