Claudin expression profile in flat wart and cutaneous squamous cell carcinoma in epidermodysplasia verruciformis

Epidermodysplasia verruciformis (EV) is a genodermatosis related to human beta-papillomavirus (beta-HPV), with a high risk of cutaneous squamous cell carcinoma (cSCC). Claudins are transmembrane proteins expressed in epithelia and may be altered during carcinogenesis. For a better understanding of t...

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Published in:Scientific reports 2020-06, Vol.10 (1), p.9268, Article 9268
Main Authors: da Cruz Silva, Lana Luiza, de Oliveira, Walmar Roncalli Pereira, Pereira, Naiura Vieira, Halpern, Ilana, Tanabe, Claudia Kwei-Fong Dai, Mattos, Mayra Servilha Grion, Sotto, Mirian N.
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Language:English
Subjects:
13/1
13/105
13/51
14/63
692/420/755
692/699/4033/1813/1352
Adolescent
Adult
Aged
Aged, 80 and over
Carcinogenesis
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Child
Child, Preschool
Claudins - metabolism
Epidermodysplasia verruciformis
Epidermodysplasia Verruciformis - metabolism
Epidermodysplasia Verruciformis - pathology
Female
Genodermatosis
Human papillomavirus
Humanities and Social Sciences
Humans
Immunohistochemistry
Male
Membrane proteins
Middle Aged
multidisciplinary
Science
Science (multidisciplinary)
Skin cancer
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Squamous cell carcinoma
Warts
Young Adult
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Sotto, Mirian N.
description Epidermodysplasia verruciformis (EV) is a genodermatosis related to human beta-papillomavirus (beta-HPV), with a high risk of cutaneous squamous cell carcinoma (cSCC). Claudins are transmembrane proteins expressed in epithelia and may be altered during carcinogenesis. For a better understanding of the role of beta-HPV in cutaneous carcinogenesis, this claudin expression study was conducted on lesions of patients with and without EV. In this study, claudins-1, -2, -3, -4, -5, -7 and -11 expressions were analyzed by applying the immunohistochemistry technique, in samples of 108 normal skin, 39 flat warts and 174 cSCC. The cSCC samples were organized in tissue microarrays. We found that claudin-1 and claudin-3 focal expressions were associated with cSCC (p 
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Claudins are transmembrane proteins expressed in epithelia and may be altered during carcinogenesis. For a better understanding of the role of beta-HPV in cutaneous carcinogenesis, this claudin expression study was conducted on lesions of patients with and without EV. In this study, claudins-1, -2, -3, -4, -5, -7 and -11 expressions were analyzed by applying the immunohistochemistry technique, in samples of 108 normal skin, 39 flat warts and 174 cSCC. The cSCC samples were organized in tissue microarrays. We found that claudin-1 and claudin-3 focal expressions were associated with cSCC (p &lt; 0.001), and claudin-2 focal or negative expression with flat wart (p &lt; 0.001), in EV and NEV (non-EV) groups. For claudin-5, EV group showed a lower chance of focal and negative expression (p &lt; 0.001), and its negative expression was associated with flat wart (p &lt; 0.001) and lower mean age (p &lt; 0.001). Claudins-4, -7 and -11 showed a diffuse expression in almost all studied samples. 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subjects 13/1
13/105
13/51
14/63
692/420/755
692/699/4033/1813/1352
Adolescent
Adult
Aged
Aged, 80 and over
Carcinogenesis
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Child
Child, Preschool
Claudins - metabolism
Epidermodysplasia verruciformis
Epidermodysplasia Verruciformis - metabolism
Epidermodysplasia Verruciformis - pathology
Female
Genodermatosis
Human papillomavirus
Humanities and Social Sciences
Humans
Immunohistochemistry
Male
Membrane proteins
Middle Aged
multidisciplinary
Science
Science (multidisciplinary)
Skin cancer
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Squamous cell carcinoma
Warts
Young Adult
title Claudin expression profile in flat wart and cutaneous squamous cell carcinoma in epidermodysplasia verruciformis
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