Physical and Biological Evaluation of Low-Molecular-Weight Hyaluronic Acid/Fe3O4 Nanoparticle for Targeting MCF7 Breast Cancer Cells

Low-molecular-weight hyaluronic acid (LMWHA) was integrated with superparamagnetic Fe3O4 nanoparticles (Fe3O4 NPs). The size distribution, zeta potential, viscosity, thermogravimetric and paramagnetic properties of the LMWHA-Fe3O4 NPs were systematically examined. For cellular experiments, MCF7 brea...

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Bibliographic Details
Published in:Polymers 2020-05, Vol.12 (5), p.1094
Main Authors: Wang, Hsin-Ta, Chou, Po-Chien, Wu, Ping-Han, Lee, Chi-Ming, Fan, Kang-Hsin, Chang, Wei-Jen, Lee, Sheng-Yang, Huang, Haw-Ming
Format: Article
Language:English
Subjects:
Arthritis
Breast cancer
Chromatography
Gamma rays
Hyaluronic acid
Hydrochloric acid
Hyperthermia
Iron oxides
Low molecular weights
Magnetic resonance imaging
Methods
Molecular weight
Nanoparticles
Potassium
Secondary ion mass spectrometry
Size distribution
Thiocyanates
Toxicity
Viscoelasticity
Viscosity
Zeta potential
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Summary:Low-molecular-weight hyaluronic acid (LMWHA) was integrated with superparamagnetic Fe3O4 nanoparticles (Fe3O4 NPs). The size distribution, zeta potential, viscosity, thermogravimetric and paramagnetic properties of the LMWHA-Fe3O4 NPs were systematically examined. For cellular experiments, MCF7 breast cancer cell line was carried out. In addition, the cell targeting ability and characteristics of the LMWHA-Fe3O4 NPs for MCF7 breast cancer cells were analyzed using the thiocyanate method and time-of-flight secondary ion mass spectrometry (TOF-SIMS). The experimental results showed that the LMWHA-Fe3O4 NPs were not only easily injectable due to their low viscosity, but also exhibited a significant superparamagnetic property. Furthermore, the in vitro assay results showed that the NPs had negligible cytotoxicity and exhibited a good cancer cell targeting ability. Overall, the results therefore suggest that the LMWHA-Fe3O4 NPs have considerable potential as an injectable agent for enhanced magnetic resonance imaging (MRI) and/or hyperthermia treatment in breast cancer therapy.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym12051094