Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch

The objective of this study was to authenticate the ethnobotanical claims of the Nepeta ruderalis Buch.-Ham. (N. ruderalis) extract in the traditional system of medicine. Crude extract was prepared via a simple maceration process. DPPH free radical scavenging and carrageenan-induced rat paw edema mo...

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Bibliographic Details
Published in:BioMed research international 2020, Vol.2020 (2020), p.1-9
Main Authors: Mehmood, Rubada, Bibi, Sumbal, Wahid, Muqeet, Imran, Imran, Janbaz, Khalid Hussain, Aleem, Ambreen, Afzal, Khurram
Format: Article
Language:English
Subjects:
Acids
Adenosine diphosphate
Agglomeration
Analysis
Angina pectoris
Animal models
Animals
Anti-Inflammatory Agents - pharmacology
Anti-inflammatory drugs
Antioxidants
Antioxidants - pharmacology
Atria
Biphenyl Compounds - metabolism
Calcium
Calcium channels
Cardiovascular Agents - pharmacology
Carrageenan
Carrageenin
Chloride
Contraction
Edema
Edema - pathology
Ethylenediaminetetraacetic acid
Experiments
Free radicals
Heart Atria - drug effects
Heart beat
Heart rate
Heart Rate - drug effects
Inflammation
Inflammatory response
Jejunum
Jejunum - drug effects
Maceration
Medicine
Nepeta
Nepeta - chemistry
Physiology
Picrates - metabolism
Plant Extracts - pharmacology
Platelet aggregation
Platelet Aggregation Inhibitors - pharmacology
Potassium
Rabbits
Rats
Scavenging
Trachea
Trachea - drug effects
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Summary:The objective of this study was to authenticate the ethnobotanical claims of the Nepeta ruderalis Buch.-Ham. (N. ruderalis) extract in the traditional system of medicine. Crude extract was prepared via a simple maceration process. DPPH free radical scavenging and carrageenan-induced rat paw edema models were used to monitor antioxidant and anti-inflammatory responses of the N. ruderalis extract. Furthermore, it was tested for antiplatelet aggregation, cardioprotective, and calcium channel antagonistic activities via standard documented protocols. The N. ruderalis extract exhibited 80.82% antioxidant activity (IC50=207.51±4.36 μg) while the anti-inflammatory response was significant (p
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/2096947