Survival of infants with spina bifida and the role of maternal prepregnancy body mass index

Objective To investigate first‐year survival of infants born with spina bifida, and examine the association of maternal prepregnancy body mass index (BMI) with infant mortality. Methods This is a retrospective cohort study of 1,533 liveborn infants with nonsyndromic spina bifida with estimated dates...

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Bibliographic Details
Published in:Birth defects research 2019-10, Vol.111 (16), p.1205-1216
Main Authors: Pace, Nelson D., Siega‐Riz, Anna Maria, Olshan, Andrew F., Chescheir, Nancy C., Cole, Stephen R., Desrosiers, Tania A., Tinker, Sarah C., Hoyt, Adrienne T., Canfield, Mark A., Carmichael, Suzan L., Meyer, Robert E.
Format: Article
Language:English
Subjects:
Adult
Babies
Birth defects
Body mass
Body Mass Index
Body size
Body weight
Case-Control Studies
Cohort Studies
Congenital defects
Female
Gestation
Health risk assessment
Humans
Infant
Infant mortality
Infant Mortality - trends
Infant, Newborn
Infants
Kaplan-Meier Estimate
Male
Maternal Behavior - physiology
mortality
Mothers
Obesity
Obesity - complications
Odds Ratio
Overweight
Pregnancy
Proportional Hazards Models
Retrospective Studies
Risk
Risk Factors
Spina bifida
Spinal Dysraphism - mortality
Statistical models
Survival
Underweight
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Summary:Objective To investigate first‐year survival of infants born with spina bifida, and examine the association of maternal prepregnancy body mass index (BMI) with infant mortality. Methods This is a retrospective cohort study of 1,533 liveborn infants with nonsyndromic spina bifida with estimated dates of delivery from 1998 to 2011 whose mothers were eligible for the National Birth Defects Prevention Study (NBDPS). NBDPS data were linked to death records to conduct survival analyses. Kaplan–Meier survival functions estimated mortality risk over the first year of life. Cox proportional hazards models estimated hazard ratios (HRs) for maternal prepregnancy BMI categorized as underweight (
ISSN:2472-1727
2472-1727
DOI:10.1002/bdr2.1552