Association of FTO and ADRB2 gene variation with energy restriction induced adaptations in resting energy expenditure and physical activity

• Published in: Gene 2019-09, Vol.721, p.100019-100019, Article 100019
• Main Authors: Camps, Stefan G.J.A., Verhoef, Sanne P.M., Bouwman, Freek G., Mariman, Edwin C.M., Westerterp, Klaas R.
• Format: Article
• Language: English
• Subjects: Adaptive thermogenesis; Energy balance; Genetic predisposition; Metabolic adaptation; Weight loss
• ISSN: 0378-1119; 1879-0038; 2590-1583
• DOI: 10.1016/j.gene.2019.100019

Energy restriction induces adaptations in resting energy expenditure (REE) and physical activity; inter-individual variability could be ascribed to genetic predisposition. The aim was to examine if changes in REE and physical activity as a result of weight loss were affected by candidate single nucleotide polymorphisms (SNPs). 148 subjects (39 men, 109 women), mean ± SD age: 41 ± 9 year; body mass index (BMI): 31.9 ± 3.0 kg/m2, followed a very low energy diet for 8 weeks. SNPs were selected from six candidate genes: ADRB2, FTO, MC4R, PPARG2, PPARD and PPARGC1A. REE (ventilated hood) and physical activity (tri-axial accelerometer) were assessed before and after the diet. General linear modelling included gender, age and additional relevant covariates for all parameters. The heterozygotic genotype of FTO was associated with a higher amount of physical activity (1.71 Mcounts/d; CI 1.62–1.81) compared to the homozygotic major genotype (1.50 Mcounts/d; CI 1.40–1.59) (P