Systemic F2-Isoprostane Levels in Predisposition to Obesity and Type 2 Diabetes: Emphasis on Racial Differences

This review focuses on racial differences in systemic levels of lipid peroxidation markers F2-isoprostanes as metabolic characteristics predisposing to obesity and type 2 diabetes. Elevated levels F2-isoprostanes were found in obesity, type 2 diabetes and their comorbidities. It was hypothesized tha...

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Bibliographic Details
Published in:Diversity and equality in health and care 2017-01, Vol.14 (2), p.91-101
Main Authors: Il'yasova, Dora, Wong, Brett J, Waterstone, Anna, Kinev, Alexander, Okosun, Ike S
Format: Article
Language:English
Subjects:
African Americans
Biomarkers
Body fat
Diabetes
Endogenous
Ethnicity
Exercise
Fitness training programs
Free radicals
Gastrointestinal surgery
Health care
Health disparities
Hispanic Americans
Hypotheses
Inequality
Lifestyles
Metabolism
Metabolites
Obesity
Oxidative stress
Oxygen
Physical fitness
Physiology
Public health
Race
Racial differences
Racial inequality
Risk factors
Type 2 diabetes mellitus
Weight control
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Summary:This review focuses on racial differences in systemic levels of lipid peroxidation markers F2-isoprostanes as metabolic characteristics predisposing to obesity and type 2 diabetes. Elevated levels F2-isoprostanes were found in obesity, type 2 diabetes and their comorbidities. It was hypothesized that increased F2-isoprostane levels reflect the obesity-induced oxidative stress that promotes the development of type 2 diabetes. However, African Americans have lower levels of systemic F2-isoprostane levels despite their predisposition to obesity and type 2 diabetes. The review summarizes new findings from epidemiological studies and a novel interpretation of metabolic determinants of systemic F2-isoprostane levels as a favorable phenotype. Multiple observations indicate that systemic F2-isoprostane levels reflect intensity of oxidative metabolism, a major endogenous source of reactive oxygen species, and specifically, the intensity of fat utilization. Evidence from multiple human studies proposes that targeting fat metabolism can be a productive race-specific strategy to address the existing racial health disparities. Urinary F2- isoprostanes may provide the basis for targeted interventions to prevent obesity and type 2 diabetes among populations of African descent.
ISSN:2049-5471
2049-5471
2049-548X
DOI:10.21767/2049-5471.100098