Noninvasive, wearable, and tunable electromagnetic multisensing system for continuous glucose monitoring, mimicking vasculature anatomy

• Published in: Science advances 2020-06, Vol.6 (24), p.eaba5320-eaba5320
• Main Authors: Hanna, Jessica, Bteich, Moussa, Tawk, Youssef, Ramadan, Ali H, Dia, Batoul, Asadallah, Fatima A, Eid, Aline, Kanj, Rouwaida, Costantine, Joseph, Eid, Assaad A
• Format: Article
• Language: English
• Subjects: Animals; Applied Sciences and Engineering; Blood Glucose; Blood Glucose Self-Monitoring - methods; Diabetes Mellitus - diagnosis; Engineering; Humans; Monitoring, Physiologic; SciAdv r-articles; Wearable Electronic Devices
• ISSN: 2375-2548; 2375-2548
• DOI: 10.1126/sciadv.aba5320

Painless, needle-free, and continuous glucose monitoring sensors are needed to enhance the life quality of diabetic patients. To that extent, we propose a first-of-its-kind, highly sensitive, noninvasive continuous glycemic monitoring wearable multisensor system. The proposed sensors are validated on serum, animal tissues, and animal models of diabetes and in a clinical setting. The noninvasive measurement results during human trials reported high correlation (>0.9) between the system's physical parameters and blood glucose levels, without any time lag. The accurate real-time responses of the sensors are attributed to their unique vasculature anatomy-inspired tunable electromagnetic topologies. These wearable apparels wirelessly sense hypo- to hyperglycemic variations with high fidelity. These components are designed to simultaneously target multiple body locations, which opens the door for the development of a closed-loop artificial pancreas.