Elevated Risk for Sessile Serrated Polyps in African Americans with Endometrial Polyps

• Published in: Digestive diseases and sciences 2020-09, Vol.65 (9), p.2686-2690
• Main Authors: Ashktorab, Hassan, Sherif, Zaki, Tarjoman, Taraneh, Azam, Saman, Lee, Edward, Shokrani, Babak, Okereke, Ifeanyichukwu, Soleimani, Akbar, Carethers, John M., Laiyemo, Adeyinka O., Aduli, Farshad, Nouraie, Mehdi, Habtezion, Aida, Brim, Hassan
• Format: Article
• Language: English
• Subjects: African Americans; Age; Aged; Biochemistry; Colonic Polyps - diagnosis; Colonic Polyps - ethnology; Colonoscopy; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - ethnology; Diabetes; Diabetes Mellitus - ethnology; Endometrium; Female; Gastroenterology; Health aspects; Hepatology; Humans; Medical colleges; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Polyps; Polyps (Pathology); Polyps - diagnosis; Polyps - ethnology; Prevalence; Race Factors; Retrospective Studies; Risk Assessment; Risk Factors; Smoking - adverse effects; Smoking - ethnology; Transplant Surgery; Uterine Diseases - diagnosis; Uterine Diseases - ethnology; Women
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-019-05991-y

Background Colorectal and endometrial lesions increase with age. It is not known if these two precursor lesions in sporadic cases associate with each other. Aim To determine the association between colorectal polyps and endometrial polyps (EP) in African Americans. Methods We reviewed records of patients referred to gynecology clinics and had colonoscopy at Howard University Hospital from January 2004 to December 2015. We defined cases as all patients who had EP and underwent colonoscopy. For controls, we used EP-free patients who underwent colonoscopy. Logistic regression analysis was used to assess the association between colon polyps and EP. Results The median age was 60 years in 118 Cases and 57 years in 664 Controls. The overall colorectal polyps prevalence in the two groups was not statistically different (54% in controls vs. 52% in cases, P  = 0.60). Sessile serrated adenoma/polyps (SSPs) were more frequent in cases (8% vs. 2% in controls, P  = 0.003). Sigmoid and rectal locations were more prevalent in controls than cases. In multivariate analysis and after adjusting for age, diabetes mellitus (DM), and BMI, SSPs were associated with EP occurrence with an odds ratio of 4.6 (CI 1.2–16.7, P  = 0.022). Conclusion Colorectal polyp prevalence was similar in EP patients compared to EP-free controls. However, we observed a significant association between higher-risk SSPs in patients with EP. The prevalence of smoking and DM was higher in these patients. Females with EP might benefit from a screening for colonic lesions in an age-independent manner.