Therapeutic effects of vitamin D on acetic acid-induced colitis in rats

Abstract Purpose To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single do...

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Published in:Acta cirúrgica brasileira 2020-01, Vol.35 (4)
Main Authors: Bademci, Refik, Erdoğan, Mümin Alper, Kara, Ali Yücel, Yiğittürk, Gürkan, Erbaş, Oytun
Format: Article
Language:English
Subjects:
Calcitriol
Colitis
Experimental Surgery
Malondialdehyde
Original
Rats
Tumor Necrosis Factor-alpha
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container_title Acta cirúrgica brasileira
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creator Bademci, Refik
Erdoğan, Mümin Alper
Kara, Ali Yücel
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Erbaş, Oytun
description Abstract Purpose To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 µg/kg for 5 days. Results Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p
doi_str_mv 10.1590/s0102-865020200040000004
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Methods A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 µg/kg for 5 days. Results Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p&lt;0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p &lt;0.000). 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subjects Calcitriol
Colitis
Experimental Surgery
Malondialdehyde
Original
Rats
Tumor Necrosis Factor-alpha
title Therapeutic effects of vitamin D on acetic acid-induced colitis in rats
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