Consuming a ketogenic diet leads to altered hypoglycemic counter-regulation in mice

Ketogenic diets (KDs) are becoming increasingly popular for the treatment of diabetes, yet they are associated with increased frequency of hypoglycemia. Here we report that mice fed a KD display blunted glucagon release to hypoglycemia and neuroglucopenia, suggesting that consuming a KD may increase...

Full description

Saved in:
Bibliographic Details
Published in:Journal of diabetes and its complications 2020-05, Vol.34 (5), p.107557-107557, Article 107557
Main Authors: Morrison, Christopher D., Hill, Cristal M., DuVall, Marina A., Coulter, Carolyn E., Gosey, Jasmin L., Herrera, Matthew J., Maisano, Lauren E., Sikaffy, Hunter X., McDougal, David H.
Format: Article
Language:English
Subjects:
Carbohydrates
Diabetes
Diabetes complications
Fasting
Glucagon
Glucose
Hypoglycemia
Insulin
Ketosis
Metabolism
Metabolites
Physiology
Writing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ketogenic diets (KDs) are becoming increasingly popular for the treatment of diabetes, yet they are associated with increased frequency of hypoglycemia. Here we report that mice fed a KD display blunted glucagon release to hypoglycemia and neuroglucopenia, suggesting that consuming a KD may increase the risk for iatrogenic hypoglycemia. •Mice fed a ketogenic diet experienced altered glucoregulatory responses to 2-DG.•Mice fed a ketogenic diet had reduced glucagon levels during insulin-induced hypoglycemia.•Mice fed a ketogenic diet had increased corticosterone levels during insulin-induced hypoglycemia.
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2020.107557