The long‐standing history of Corynebacterium parvum, immunity, and viruses

We report a review of all the experimental and clinical studies performed in the last 60 years on the antiviral activity of inactivated Corynebacterium parvum (Cutibacterium acnes). This bacterium has been originally investigated and used for its oncolytic properties linked to immunomodulating activ...

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Bibliographic Details
Published in:Journal of medical virology 2020-11, Vol.92 (11), p.2429-2439
Main Authors: Palmieri, Beniamino, Vadalà, Maria, Roncati, Luca, Garelli, Andrea, Scandone, Francesco, Bondi, Moreno, Cermelli, Claudio
Format: Article
Language:English
Subjects:
Animals
Antiviral activity
C. parvum
Clinical Trials as Topic
coronavirus
Corynebacterium
COVID-19
COVID-19 - prevention & control
Humans
immune responses
Immunity
Immunity, Innate
Immunologic Factors - administration & dosage
Immunologic Factors - therapeutic use
Immunologic Surveillance
immunomodulation
Immunosurveillance
Innate immunity
Lethality
Oncolysis
Pandemics
Propionibacterium acnes - immunology
Review
Reviews
Virology
Virus Diseases - immunology
Virus Diseases - prevention & control
Virus Diseases - therapy
Viruses
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Summary:We report a review of all the experimental and clinical studies performed in the last 60 years on the antiviral activity of inactivated Corynebacterium parvum (Cutibacterium acnes). This bacterium has been originally investigated and used for its oncolytic properties linked to immunomodulating activity, but the interest to successfully prevent and treat bacterial, fungal, and viral infections and lethality, uprising the innate immunity barriers produced many experimental models and very few clinical studies. The dramatic defenseless situation due to impending CoViD‐19 pandemic claims to exhume and highlight this aspecific strategy in preventive and therapeutic settings; as a matter of fact, no new or mutated virus can potentially escape to this strong innate immune surveillance strengthened by adequate C. parvum protocols.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.26100