New IgM seroconversion and positive RT‐PCR test after exposure to the virus in recovered COVID‐19 patient

To date, understanding whether acquired immunity and presence of anti SARS‐Cov2 antibodies protects against reinfection is one the most important focus of the scientific community [1‐2]. Several studies suggest that acquired immunity may protect upon further exposure to SARS‐COV2 [3‐6]. Contrary to...

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Bibliographic Details
Published in:Journal of Medical Virology 2021-01, Vol.93 (1), p.97-98
Main Authors: Bentivegna, Enrico, Sentimentale, Alberto, Luciani, Michelangelo, Speranza, Maria Letizia, Guerritore, Ludovica, Martelletti, Paolo
Format: Article
Language:English
Subjects:
Aged
Antibodies, Viral - blood
COVID-19
COVID-19 - diagnosis
COVID-19 - immunology
COVID-19 - virology
Female
Humans
Immunoglobulin M
Immunoglobulin M - blood
Letter to the Editor
Reverse Transcriptase Polymerase Chain Reaction - methods
Seroconversion
Virology
Viruses
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Summary:To date, understanding whether acquired immunity and presence of anti SARS‐Cov2 antibodies protects against reinfection is one the most important focus of the scientific community [1‐2]. Several studies suggest that acquired immunity may protect upon further exposure to SARS‐COV2 [3‐6]. Contrary to this picture, we describe a case of a patient recovered from COVID‐19 pneumonia with positive serology, followed up by 6 negative nasopharyngeal swab‐PCR tests performed along 1 month, who later on, after exposure to the virus, presented another positive RT‐PCR test and a second IgM seroconversion. This report opens up several possible interpretations.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.26160