The Gut Microbiome as a Therapeutic Target for Cognitive Impairment

Abstract Declining cognitive functions in older individuals have enormous emotional, clinical, and public health consequences. Thus, therapeutics for preserving function and keeping older adults living independently are imperative. Aging is associated dysbiosis, defined as a loss of number and diver...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2020-06, Vol.75 (7), p.1242-1250
Main Authors: Sun, Yi, Baptista, Liliana C, Roberts, Lisa M, Jumbo-Lucioni, Patricia, McMahon, Lori L, Buford, Thomas W, Carter, Christy S
Format: Article
Language:English
Subjects:
Aging
Cognitive ability
Cognitive Dysfunction - etiology
Cognitive Dysfunction - pathology
Cognitive Dysfunction - prevention & control
Dementia
Diet
Dietary Fiber - administration & dosage
Digestive system
Dysbacteriosis
Exercise
Fecal Microbiota Transplantation
Fecal microflora
Gastrointestinal Microbiome - physiology
Humans
Intestinal microflora
Medical treatment
Microbiomes
Microbiota
Older people
Probiotics
Probiotics - therapeutic use
Public health
Special Issue: The Gut Microbiome and Aging
Therapeutic applications
Transplantation
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Summary:Abstract Declining cognitive functions in older individuals have enormous emotional, clinical, and public health consequences. Thus, therapeutics for preserving function and keeping older adults living independently are imperative. Aging is associated dysbiosis, defined as a loss of number and diversity in gut microbiota, which has been linked with various aspects of cognitive functions. Therefore, the gut microbiome has the potential to be an important therapeutic target for symptoms of cognitive impairment. In this review, we summarize the current literature regarding the potential for gut-targeted therapeutic strategies for prevention/treatment of the symptoms of cognitive impairment. Specifically, we discuss four primary therapeutic strategies: wild-type and genetically modified probiotics, fecal microbiota transplantation, physical exercise, and high-fiber diets and specifically link these therapies to reducing inflammation. These strategies may hold promise as treatment paradigm symptoms related to cognitive impairment.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glz281