Moderately HRT vs. CRT for localized prostate cancer using image-guided VMAT with SIB: evaluation of acute and late toxicities

Purpose This retrospective study aims at investigating the effects of moderately hypofractionated radiation therapy (HRT) on acute and late toxicities as well as on early biochemical control and therapeutic efficiency compared to conventional radiation therapy (CRT) in prostate cancer. Patients and...

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Bibliographic Details
Published in:Strahlentherapie und Onkologie 2020-07, Vol.196 (7), p.598-607
Main Authors: Vassis, Stratos, Nöldeke, Beatrice, Christiansen, Hans, von Klot, Christoph A., Merten, Roland
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood
Adenocarcinoma - pathology
Adenocarcinoma - radiotherapy
Aged
Aged, 80 and over
Antigens
Computed tomography
Continuity (mathematics)
Cystitis - etiology
Cystitis - pathology
Evaluation
Follow-Up Studies
Gastrointestinal Diseases - etiology
Gastrointestinal Diseases - prevention & control
Humans
Male
Matching
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Oncology
Organ Sparing Treatments - methods
Organs at Risk - radiation effects
Original
Original Article
Proctitis - etiology
Proctitis - prevention & control
Propensity Score
Prostate cancer
Prostate-Specific Antigen - blood
Prostatic Neoplasms - blood
Prostatic Neoplasms - pathology
Prostatic Neoplasms - radiotherapy
Radiation Dose Hypofractionation
Radiation Injuries - etiology
Radiation Injuries - prevention & control
Radiation therapy
Radiotherapy
Radiotherapy, Intensity-Modulated - adverse effects
Radiotherapy, Intensity-Modulated - methods
Rectum
Rectum - radiation effects
Retrospective Studies
Seminal Vesicles - pathology
Seminal Vesicles - radiation effects
Statistical analysis
Statistical tests
Terminology
Time Factors
Tumor Burden
Urinary Bladder - radiation effects
Urination Disorders - etiology
Urination Disorders - pathology
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Summary:Purpose This retrospective study aims at investigating the effects of moderately hypofractionated radiation therapy (HRT) on acute and late toxicities as well as on early biochemical control and therapeutic efficiency compared to conventional radiation therapy (CRT) in prostate cancer. Patients and methods We analyzed 55 HRT patients irradiated with the total dose of 60 Gy in 20 fractions delivered over 4 weeks. These patients were compared to a control group of 55 patients who received CRT with a total of
ISSN:0179-7158
1439-099X
DOI:10.1007/s00066-020-01589-w