Functionality of decellularized matrix in cartilage regeneration: A comparison of tissue versus cell sources

[Display omitted] Increasing evidence indicates that decellularized extracellular matrices (dECMs) derived from cartilage tissues (T-dECMs) or chondrocytes/stem cells (C-dECMs) can support proliferation and chondrogenic differentiation of cartilage-forming cells. However, few review papers compare t...

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Bibliographic Details
Published in:Acta biomaterialia 2018-07, Vol.74, p.56-73
Main Authors: Sun, Yu, Yan, Lianqi, Chen, Song, Pei, Ming
Format: Article
Language:English
Subjects:
Animals
Cartilage
Cartilage - physiology
Cartilage regeneration
Cell growth
Cell proliferation
Chondrocyte
Chondrocytes
Chondrocytes - metabolism
Chondrogenesis
Chondrogenic differentiation
Computer architecture
Decellularized matrix
Differentiation
Extracellular matrix
Extracellular Matrix - chemistry
Humans
Immunogenicity
Proliferation
Regeneration
Reviews
Stem cell
Stem cells
Stem Cells - metabolism
Substrates
Tissue engineering
Tissue Engineering - methods
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Summary:[Display omitted] Increasing evidence indicates that decellularized extracellular matrices (dECMs) derived from cartilage tissues (T-dECMs) or chondrocytes/stem cells (C-dECMs) can support proliferation and chondrogenic differentiation of cartilage-forming cells. However, few review papers compare the differences between these dECMs when they serve as substrates for cartilage regeneration. In this review, after an introduction of cartilage immunogenicity and decellularization methods to prepare T-dECMs and C-dECMs, a comprehensive comparison focuses on the effects of T-dECMs and C-dECMs on proliferation and chondrogenic differentiation of chondrocytes/stem cells in vitro and in vivo. Key factors within dECMs, consisting of microarchitecture characteristics and micromechanical properties as well as retained insoluble and soluble matrix components, are discussed in-depth for potential mechanisms underlying the functionality of these dECMs in regulating chondrogenesis. With this information, we hope to benefit dECM based cartilage engineering and tissue regeneration for future clinical application. The use of decellularized extracellular matrix (dECM) is becoming a promising approach for tissue engineering and regeneration. Compared to dECM derived from cartilage tissue, recently reported dECM from cell sources exhibits a distinct role in cell based cartilage regeneration. In this review paper, for the first time, tissue and cell based dECMs are comprehensively compared for their functionality in cartilage regeneration. This information is expected to provide an update for dECM based cartilage regeneration.
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2018.04.048