Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy

Summary Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the...

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Bibliographic Details
Published in:British journal of cancer 2020-09, Vol.123 (5), p.694-697
Main Authors: Saini, Kamal S., Lanza, Carlo, Romano, Marco, de Azambuja, Evandro, Cortes, Javier, de las Heras, Begoña, de Castro, Javier, Lamba Saini, Monika, Loibl, Sibylle, Curigliano, Giuseppe, Twelves, Chris, Leone, Manuela, Patnaik, Mrinal M.
Format: Article
Language:English
Subjects:
692/308/153
692/4028/67/1059/153
692/699/255/2514
Adrenal Cortex Hormones - therapeutic use
Anticoagulants - therapeutic use
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Antineoplastic drugs
Antitumor agents
Betacoronavirus
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Comment
Coronavirus Infections - drug therapy
Coronavirus Infections - immunology
Coronavirus Infections - physiopathology
Coronavirus Infections - virology
Coronaviruses
COVID-19
Drug Repositioning - methods
Drug Resistance
Epidemiology
Humans
Immunologic Factors - therapeutic use
Immunosuppressive agents
Inflammation
Inflammation - drug therapy
Interleukin-6 - antagonists & inhibitors
Molecular Medicine
Oncology
Pandemics
Pneumonia, Viral - drug therapy
Pneumonia, Viral - immunology
Pneumonia, Viral - physiopathology
Pneumonia, Viral - virology
Programmed Cell Death 1 Receptor - antagonists & inhibitors
Protein Kinase Inhibitors - therapeutic use
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Treatment Outcome
Vascular Endothelial Growth Factor A - antagonists & inhibitors
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Description
Summary:Summary Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the course of COVID-19.
ISSN:0007-0920
1532-1827
DOI:10.1038/s41416-020-0948-x