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Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis
Atrial fibrillation (AF) has traditionally been considered an electrical heart disease. However, genetic studies have revealed that the structural architecture of the heart also play a significant role. We evaluated the functional and structural consequences of harboring a titin-truncating variant (...
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| Published in: | Scientific reports 2020-06, Vol.10 (1), p.10039-10039, Article 10039 |
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| creator | Andreasen, Laura Bertelsen, Litten Ghouse, Jonas Lundegaard, Pia R. Ahlberg, Gustav Refsgaard, Lena Rasmussen, Torsten B. Eiskjær, Hans Haunsø, Stig Vejlstrup, Niels Svendsen, Jesper H. Olesen, Morten S. |
| description | Atrial fibrillation (AF) has traditionally been considered an electrical heart disease. However, genetic studies have revealed that the structural architecture of the heart also play a significant role. We evaluated the functional and structural consequences of harboring a titin-truncating variant (TTNtv) in AF patients, using cardiac magnetic resonance (CMR). Seventeen early-onset AF cases carrying a TTNtv, were matched 1:1 with non-AF controls and a replication cohort of early-onset AF cases without TTNtv, and underwent CMR. Cardiac volumes and left atrial late gadolinium enhancement (LA LGE), as a fibrosis proxy, were measured by a blinded operator. Results: AF cases with TTNtv had significantly reduced left ventricular ejection fraction (LVEF) compared with controls (57 ± 4 vs 64 ± 5%, P |
| doi_str_mv | 10.1038/s41598-020-66671-w |
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However, genetic studies have revealed that the structural architecture of the heart also play a significant role. We evaluated the functional and structural consequences of harboring a titin-truncating variant (TTNtv) in AF patients, using cardiac magnetic resonance (CMR). Seventeen early-onset AF cases carrying a TTNtv, were matched 1:1 with non-AF controls and a replication cohort of early-onset AF cases without TTNtv, and underwent CMR. Cardiac volumes and left atrial late gadolinium enhancement (LA LGE), as a fibrosis proxy, were measured by a blinded operator. Results: AF cases with TTNtv had significantly reduced left ventricular ejection fraction (LVEF) compared with controls (57 ± 4 vs 64 ± 5%, P < 0.001). We obtained similar findings in early-onset AF patients without TTNtv compared with controls (61 ± 4 vs 64 ± 5%, P = 0.02). We furthermore found a statistically significant increase in LA LGE when comparing early-onset AF TTNtv cases with controls. Using state-of-the-art CMR, we found that early-onset AF patients, irrespective of TTNtv carrier status, had reduced LVEF, indicating that early-onset AF might not be as benign as previously thought.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-66671-w</identifier><identifier>PMID: 32572052</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/2489/144 ; 692/4019/592/2727 ; 692/4019/592/75 ; Adult ; Age ; Age of Onset ; Atrial Fibrillation - diagnostic imaging ; Atrial Fibrillation - genetics ; Atrial Fibrillation - pathology ; Atrial Fibrillation - physiopathology ; Cardiac arrhythmia ; Cardiovascular diseases ; Case-Control Studies ; Connectin ; Connectin - genetics ; Contrast Media - administration & dosage ; Coronary artery disease ; Ejection fraction ; Female ; Fibrillation ; Fibrosis ; Gadolinium ; Gadolinium - administration & dosage ; Heart diseases ; Humanities and Social Sciences ; Humans ; Magnetic Resonance Imaging, Cine ; Male ; multidisciplinary ; Mutation ; Radiographic Image Interpretation, Computer-Assisted ; Science ; Science (multidisciplinary) ; Statistical analysis ; Structure-function relationships ; Ventricle ; Ventricular Function, Left ; Young Adult</subject><ispartof>Scientific reports, 2020-06, Vol.10 (1), p.10039-10039, Article 10039</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-958a9d4fcdb8ed8128f38e37a27c9543a2a1e7402f1dc5c9cbffd1a123df9fe03</citedby><cites>FETCH-LOGICAL-c474t-958a9d4fcdb8ed8128f38e37a27c9543a2a1e7402f1dc5c9cbffd1a123df9fe03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2415568995/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2415568995?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32572052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andreasen, Laura</creatorcontrib><creatorcontrib>Bertelsen, Litten</creatorcontrib><creatorcontrib>Ghouse, Jonas</creatorcontrib><creatorcontrib>Lundegaard, Pia R.</creatorcontrib><creatorcontrib>Ahlberg, Gustav</creatorcontrib><creatorcontrib>Refsgaard, Lena</creatorcontrib><creatorcontrib>Rasmussen, Torsten B.</creatorcontrib><creatorcontrib>Eiskjær, Hans</creatorcontrib><creatorcontrib>Haunsø, Stig</creatorcontrib><creatorcontrib>Vejlstrup, Niels</creatorcontrib><creatorcontrib>Svendsen, Jesper H.</creatorcontrib><creatorcontrib>Olesen, Morten S.</creatorcontrib><title>Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Atrial fibrillation (AF) has traditionally been considered an electrical heart disease. However, genetic studies have revealed that the structural architecture of the heart also play a significant role. We evaluated the functional and structural consequences of harboring a titin-truncating variant (TTNtv) in AF patients, using cardiac magnetic resonance (CMR). Seventeen early-onset AF cases carrying a TTNtv, were matched 1:1 with non-AF controls and a replication cohort of early-onset AF cases without TTNtv, and underwent CMR. Cardiac volumes and left atrial late gadolinium enhancement (LA LGE), as a fibrosis proxy, were measured by a blinded operator. Results: AF cases with TTNtv had significantly reduced left ventricular ejection fraction (LVEF) compared with controls (57 ± 4 vs 64 ± 5%, P < 0.001). We obtained similar findings in early-onset AF patients without TTNtv compared with controls (61 ± 4 vs 64 ± 5%, P = 0.02). We furthermore found a statistically significant increase in LA LGE when comparing early-onset AF TTNtv cases with controls. Using state-of-the-art CMR, we found that early-onset AF patients, irrespective of TTNtv carrier status, had reduced LVEF, indicating that early-onset AF might not be as benign as previously thought.</description><subject>631/208/2489/144</subject><subject>692/4019/592/2727</subject><subject>692/4019/592/75</subject><subject>Adult</subject><subject>Age</subject><subject>Age of Onset</subject><subject>Atrial Fibrillation - diagnostic imaging</subject><subject>Atrial Fibrillation - genetics</subject><subject>Atrial Fibrillation - pathology</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular diseases</subject><subject>Case-Control Studies</subject><subject>Connectin</subject><subject>Connectin - genetics</subject><subject>Contrast Media - administration & dosage</subject><subject>Coronary artery disease</subject><subject>Ejection fraction</subject><subject>Female</subject><subject>Fibrillation</subject><subject>Fibrosis</subject><subject>Gadolinium</subject><subject>Gadolinium - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andreasen, Laura</au><au>Bertelsen, Litten</au><au>Ghouse, Jonas</au><au>Lundegaard, Pia R.</au><au>Ahlberg, Gustav</au><au>Refsgaard, Lena</au><au>Rasmussen, Torsten B.</au><au>Eiskjær, Hans</au><au>Haunsø, Stig</au><au>Vejlstrup, Niels</au><au>Svendsen, Jesper H.</au><au>Olesen, Morten S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-06-22</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>10039</spage><epage>10039</epage><pages>10039-10039</pages><artnum>10039</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Atrial fibrillation (AF) has traditionally been considered an electrical heart disease. However, genetic studies have revealed that the structural architecture of the heart also play a significant role. We evaluated the functional and structural consequences of harboring a titin-truncating variant (TTNtv) in AF patients, using cardiac magnetic resonance (CMR). Seventeen early-onset AF cases carrying a TTNtv, were matched 1:1 with non-AF controls and a replication cohort of early-onset AF cases without TTNtv, and underwent CMR. Cardiac volumes and left atrial late gadolinium enhancement (LA LGE), as a fibrosis proxy, were measured by a blinded operator. Results: AF cases with TTNtv had significantly reduced left ventricular ejection fraction (LVEF) compared with controls (57 ± 4 vs 64 ± 5%, P < 0.001). We obtained similar findings in early-onset AF patients without TTNtv compared with controls (61 ± 4 vs 64 ± 5%, P = 0.02). We furthermore found a statistically significant increase in LA LGE when comparing early-onset AF TTNtv cases with controls. Using state-of-the-art CMR, we found that early-onset AF patients, irrespective of TTNtv carrier status, had reduced LVEF, indicating that early-onset AF might not be as benign as previously thought.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32572052</pmid><doi>10.1038/s41598-020-66671-w</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/208/2489/144 692/4019/592/2727 692/4019/592/75 Adult Age Age of Onset Atrial Fibrillation - diagnostic imaging Atrial Fibrillation - genetics Atrial Fibrillation - pathology Atrial Fibrillation - physiopathology Cardiac arrhythmia Cardiovascular diseases Case-Control Studies Connectin Connectin - genetics Contrast Media - administration & dosage Coronary artery disease Ejection fraction Female Fibrillation Fibrosis Gadolinium Gadolinium - administration & dosage Heart diseases Humanities and Social Sciences Humans Magnetic Resonance Imaging, Cine Male multidisciplinary Mutation Radiographic Image Interpretation, Computer-Assisted Science Science (multidisciplinary) Statistical analysis Structure-function relationships Ventricle Ventricular Function, Left Young Adult |
| title | Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis |
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