The acid response network of Staphylococcus aureus

[Display omitted] Staphylococcus aureus colonizes or causes infection in a multitude of niches within a mammalian host. Many of these niches are acidic, yet specific pH resistance mechanisms that facilitate survival have not been thoroughly investigated. This review discusses recent studies document...

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Bibliographic Details
Published in:Current opinion in microbiology 2020-06, Vol.55, p.67-73
Main Authors: Zhou, Chunyi, Fey, Paul D
Format: Article
Language:English
Subjects:
Bacterial Proteins - physiology
Gene Expression Regulation, Bacterial
Humans
Hydrogen-Ion Concentration
Metabolic Networks and Pathways
Regulon
Second Messenger Systems
Staphylococcal Infections - microbiology
Staphylococcus aureus - genetics
Staphylococcus aureus - physiology
Stress, Physiological
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Summary:[Display omitted] Staphylococcus aureus colonizes or causes infection in a multitude of niches within a mammalian host. Many of these niches are acidic, yet specific pH resistance mechanisms that facilitate survival have not been thoroughly investigated. This review discusses recent studies documenting known acid resistance mechanisms in S. aureus and other staphylococcal species. However, studies that clearly define the regulation of the acid resistance regulon and potential interactions with weak organic acids in specific niches of the host including the skin and gut are yet to be defined.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2020.03.006