Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19

Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothes...

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Bibliographic Details
Published in:Microbes and infection 2020-10, Vol.22 (9), p.405-406
Main Authors: Coish, Jeremia M., MacNeil, Adam J.
Format: Article
Language:English
Subjects:
Antibodies, Neutralizing - biosynthesis
Antibodies, Viral - biosynthesis
Antibody-Dependent Enhancement
Betacoronavirus - immunology
Betacoronavirus - pathogenicity
Coronavirus Infections - epidemiology
Coronavirus Infections - immunology
Coronavirus Infections - prevention & control
Coronavirus Infections - psychology
COVID-19
COVID-19 Vaccines
Humans
Pandemics - prevention & control
Patient Safety
Pneumonia, Viral - epidemiology
Pneumonia, Viral - immunology
Pneumonia, Viral - prevention & control
Pneumonia, Viral - psychology
SARS-CoV-2
Severity of Illness Index
Vaccination - adverse effects
Vaccination - psychology
Vaccination Refusal - psychology
Viral Vaccines - administration & dosage
Viral Vaccines - adverse effects
Virus Replication
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Description
Summary:Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Whether SARS-CoV-2 is augmented by ADE remains undetermined and has therefore garnered criticism for the improper attribution of the phenomenon to the pandemic. Thus, critical evaluation of ADE in SARS-CoV-2 vaccine development will be indispensable to avoid a global setback and the erosion of public trust.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2020.06.006