Implications of Skeletal Muscle Extracellular Matrix Remodeling in Metabolic Disorders: Diabetes Perspective

The extracellular matrix (ECM) provides a scaffold for cells, controlling biological processes and providing structural as well as mechanical support to surrounding cells. Disruption of ECM homeostasis results in several pathological conditions. Skeletal muscle ECM is a complex network comprising co...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-05, Vol.21 (11), p.3845
Main Authors: Ahmad, Khurshid, Choi, Inho, Lee, Yong-Ho
Format: Article
Language:English
Subjects:
Animals
Biological activity
Cell adhesion & migration
Collagen
Collagen - metabolism
Diabetes
Diabetes mellitus
Diabetes Mellitus - metabolism
Disease
Drug development
Elastin
Elastin - metabolism
Extracellular matrix
Extracellular Matrix - metabolism
Gene expression
Glycoproteins
Homeostasis
Humans
Insulin
Insulin Resistance
Integrins
Integrins - metabolism
Laminin - metabolism
Metabolic Diseases - metabolism
Metabolic disorders
Mice
Muscle, Skeletal - metabolism
Muscles
Muscular dystrophy
Musculoskeletal system
Myogenesis
Obesity
Physiology
Proteins
Proteoglycans
Rats
Review
Skeletal muscle
Tensile strength
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Summary:The extracellular matrix (ECM) provides a scaffold for cells, controlling biological processes and providing structural as well as mechanical support to surrounding cells. Disruption of ECM homeostasis results in several pathological conditions. Skeletal muscle ECM is a complex network comprising collagens, proteoglycans, glycoproteins, and elastin. Recent therapeutic approaches targeting ECM remodeling have been extensively deliberated. Various ECM components are typically found to be augmented in the skeletal muscle of obese and/or diabetic humans. Skeletal muscle ECM remodeling is thought to be a feature of the pathogenic milieu allied with metabolic dysregulation, obesity, and eventual diabetes. This narrative review explores the current understanding of key components of skeletal muscle ECM and their specific roles in the regulation of metabolic diseases. Additionally, we discuss muscle-specific integrins and their role in the regulation of insulin sensitivity. A better understanding of the importance of skeletal muscle ECM remodeling, integrin signaling, and other factors that regulate insulin activity may help in the development of novel therapeutics for managing diabetes and other metabolic disorders.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21113845