Role of Serotonin Transporter in Eye Development of Drosophila melanogaster

Serotonin transporter (SerT) in the brain is an important neurotransmitter transporter involved in mental health. However, its role in peripheral organs is poorly understood. In this study, we investigated the function of SerT in the development of the compound eye in . We found that SerT knockdown...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2020-06, Vol.21 (11), p.4086
Main Authors: Pham, Tuan L A, Binh, Tran Duy, Liu, Guanchen, Nguyen, Thanh Q C, Nguyen, Yen D H, Sahashi, Ritsuko, Men, Tran Thanh, Kamei, Kaeko
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Animals
Antibodies
Apoptosis
Apoptosis - genetics
Biomarkers
Caspases
Cell cycle
Cell death
Compound eye
Deoxyribonucleic acid
DNA
Drosophila melanogaster
Drosophila melanogaster - embryology
Drosophila melanogaster - genetics
Drosophila melanogaster - metabolism
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Eye - embryology
Gene Expression Regulation, Developmental
Gene Knockdown Techniques
Genotype & phenotype
Insects
Kinases
Mental health
Nervous system
Neurotransmitters
Organogenesis - genetics
Organs
Phenotype
Phenotypes
Phosphatidylinositol 3-Kinases - metabolism
Photoreceptors
Proteins
Proto-Oncogene Proteins c-akt - metabolism
Serotonin
Serotonin Plasma Membrane Transport Proteins - genetics
Serotonin Plasma Membrane Transport Proteins - metabolism
Serotonin transporter
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Serotonin transporter (SerT) in the brain is an important neurotransmitter transporter involved in mental health. However, its role in peripheral organs is poorly understood. In this study, we investigated the function of SerT in the development of the compound eye in . We found that SerT knockdown led to excessive cell death and an increased number of cells in S-phase in the posterior eye imaginal disc. Furthermore, the knockdown of in the eye disc suppressed the activation of Akt, and the introduction of effectively rescued this phenotype. These results suggested that SerT plays a role in the healthy eye development of by controlling cell death through the regulation of the PI3K/Akt pathway.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21114086