Efficacy of Ethyl Acetate Fraction of Cordyceps militaris for Cancer-Related Fatigue in Blood Biochemical and 1H-Nuclear Magnetic Resonance Metabolomic Analyses

This study investigated the adjuvant effects for anticancer and antifatigue of the combination of Cordyceps militaris extract with sorafenib. The 5 extracts of C militaris were obtained through hexane, chloroform, ethyl acetate, butanol, and water and were evaluated for anticancer growth activity. A...

Full description

Saved in:
Bibliographic Details
Published in:Integrative cancer therapies 2020-06, Vol.19, p.1534735420932635-1534735420932635
Main Authors: Oh, Junsang, Choi, Eunhyun, Kim, Jayoung, Kim, Heesu, Lee, Sangheun, Sung, Gi-Ho
Format: Article
Language:English
Subjects:
Acetic acid
Biochemical analysis
Butanol
Cancer
Chloroform
Cordyceps militaris
Ethyl acetate
Fatigue
Hepatocellular carcinoma
Liver cancer
Metabolomics
NMR
Nuclear magnetic resonance
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study investigated the adjuvant effects for anticancer and antifatigue of the combination of Cordyceps militaris extract with sorafenib. The 5 extracts of C militaris were obtained through hexane, chloroform, ethyl acetate, butanol, and water and were evaluated for anticancer growth activity. Among these extracts, ethyl acetate extract of C militaris showed the best tumor growth inhibitory activity and the adjuvant effects in combination with sorafenib. As a result of biochemical analysis with serum, the combination of ethyl acetate extract of C militaris with sorafenib showed the adjuvant effects both improving hepatic function and relieving cancer-related fatigue. In addition, 1H-nuclear magnetic resonance–based metabolic profiling in liver tissues showed that the change of metabolism by ethyl acetate extract of C militaris with sorafenib was related with serum fatigue biomarkers. Therefore, the combination strategy such as ethyl acetate extraction of C militaris with sorafenib constitutes a promising therapeutic strategy in hepatocellular carcinoma, via the inhibition of cancer growth, the enhancement of liver function, as well as the alleviation of cancer-related fatigue.
ISSN:1534-7354
1552-695X
DOI:10.1177/1534735420932635