Hsa_circ_0003732 promotes osteosarcoma cells proliferation via miR-545/CCNA2 axis

Osteosarcoma (OS) is a primary malignant bone tumor with a high fatality rate. Circular RNAs (circRNAs) are a type of endogenous noncoding RNA that have been verified to participate in cancer pathophysiological processes. We aim to investigate the roles of circRNAs in osteosarcoma tumorigenesis. In...

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Bibliographic Details
Published in:Bioscience reports 2020-06, Vol.40 (6)
Main Authors: Li, Li, Kong, Xiang-An, Zang, Mousheng, Dong, Jisheng, Feng, Yingqi, Gui, Binjie, Hu, Yong
Format: Article
Language:English
Subjects:
Bone Neoplasms - genetics
Bone Neoplasms - metabolism
Bone Neoplasms - pathology
Cancer
Cell Cycle, Growth & Proliferation
Cell Proliferation
Cyclin A2 - genetics
Cyclin A2 - metabolism
Gene Expression & Regulation
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
Osteosarcoma - genetics
Osteosarcoma - metabolism
Osteosarcoma - pathology
RNA
RNA, Circular - genetics
RNA, Circular - metabolism
Signal Transduction
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Summary:Osteosarcoma (OS) is a primary malignant bone tumor with a high fatality rate. Circular RNAs (circRNAs) are a type of endogenous noncoding RNA that have been verified to participate in cancer pathophysiological processes. We aim to investigate the roles of circRNAs in osteosarcoma tumorigenesis. In the present study, we showed that hsa_circ_0003732 was up-regulated in OS tissues and elevated level of hsa_circ_0003732 was linked to poor prognosis of OS patients. Functional investigation indicated that hsa_circ_0003732 promoted proliferation of OS cells. Furthermore, we identified miR-545 as the hsa_circ_0003732-associated microRNA and CCNA2 was a direct target of miR-545. In addition, hsa_circ_0003732 could elevate CCNA2 expression via miR-545, resulting in the promotion of OS cells proliferation. Altogether, our findings demonstrate that hsa_circ_0003732 promotes OS cells proliferation via miR-545/CCNA2 axis and imply hsa_circ_0003732 may be a potential prognosis biomarker and therapeutic target for OS.
ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20191552