HyPE study: hydroxychloroquine prophylaxis-related adverse events’ analysis among healthcare workers during COVID-19 pandemic: a rising public health concern

Abstract Background The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature. Methods A retrospective, cross-sectional study was cond...

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Bibliographic Details
Published in:Journal of Public Health 2020-08, Vol.42 (3), p.493-503
Main Authors: Nagaraja, Bada Sharanappa, Ramesh, Kalhalli Narayanaswamy, Dhar, Debjyoti, Mondal, Mahammad Samim, Dey, Treshita, Saha, Subhrakamal, Khan, Mumtaz Ali, Rutul, Shah Dhiren, Pratik, Kishore, Manjula, Jayaram, Sangeeth, Thuppanattumadam Ananthasubramanian, Singh, Vikram
Format: Article
Language:English
Subjects:
Adult
Antiviral Agents - adverse effects
Antiviral Agents - therapeutic use
Coronavirus Infections - drug therapy
Coronavirus Infections - epidemiology
COVID-19
Cross-Sectional Studies
Female
Health Personnel - statistics & numerical data
Humans
Hydroxychloroquine - adverse effects
Hydroxychloroquine - therapeutic use
Incidence
India - epidemiology
Male
Middle Aged
Original
Pandemics
Pneumonia, Viral - drug therapy
Pneumonia, Viral - epidemiology
Public Health - statistics & numerical data
Retrospective Studies
Risk Assessment
Risk Factors
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Summary:Abstract Background The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature. Methods A retrospective, cross-sectional study was conducted across the country using semi-structured web-based questionnaire among COVID-19 negative and asymptomatic healthcare workers, taking hydroxychloroquine prophylaxis. Descriptive and multivariate logistic-regression models were applied for analysis. Results Of the 166 participants, at least one adverse event was experienced by 37.9% participants, gastrointestinal being the most common (30.7%). Risk was higher in participants
ISSN:1741-3842
1741-3850
DOI:10.1093/pubmed/fdaa074