APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and shortness of breath being common. In older adults, it has been found that preexisting dementia is a major risk factor for COVID-19 severity in the UK Biobank (UKB). In another UK study of 16,749 patients hospita...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2020-11, Vol.75 (11), p.2231-2232
Main Authors: Kuo, Chia-Ling, Pilling, Luke C, Atkins, Janice L, Masoli, Jane A H, Delgado, João, Kuchel, George A, Melzer, David
Format: Article
Language:English
Subjects:
Aged
Alzheimer's disease
Apolipoprotein E4
Apolipoprotein E4 - genetics
Betacoronavirus - physiology
Biological Specimen Banks
Comorbidity
Coronavirus Infections - epidemiology
Coronavirus Infections - genetics
Coronavirus Infections - physiopathology
Coronavirus Infections - virology
Cough
COVID-19
Delirium
Dementia
Dementia disorders
England - epidemiology
Female
Fever
Genetic Predisposition to Disease
Genotypes
Homozygote
Humans
Male
Neurodegenerative diseases
Older people
Pandemics
Pneumonia, Viral - epidemiology
Pneumonia, Viral - genetics
Pneumonia, Viral - physiopathology
Pneumonia, Viral - virology
Polymorphism, Single Nucleotide
Respiratory diseases
Risk factors
SARS-CoV-2
Severity of Illness Index
Survival Analysis
THE JOURNAL OF GERONTOLOGY: Medical Sciences
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Summary:The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and shortness of breath being common. In older adults, it has been found that preexisting dementia is a major risk factor for COVID-19 severity in the UK Biobank (UKB). In another UK study of 16,749 patients hospitalized for COVID-19, dementia was among the common comorbidities and was associated with higher mortality. Additionally, impaired consciousness, including delirium, is common in severe cases. The ApoE e4 genotype is associated with both dementia and delirium, with the e4e4 (homozygous) genotype associated with a 14-fold increase in risk of Alzheimer's disease compared to the common e3e3 genotype, in populations with European ancestries. The need to test associations between ApoE e4 alleles and COVID-19 severity, using the UKB data, is also emphasized.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glaa131