Effect of an antioxidant supplement containing high dose lutein and zeaxanthin on macular pigment and skin carotenoid levels

The effect of a high dose lutein/zeaxanthin supplement on macular pigment optical density (MPOD) and skin carotenoid (SC) levels in healthy subjects was investigated. This is a prospective, single-arm, open-label study. Subjects were 16 Japanese, age 26–57 years. Subjects took a supplement containin...

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Bibliographic Details
Published in:Scientific reports 2020-06, Vol.10 (1), p.10262, Article 10262
Main Authors: Obana, Akira, Gohto, Yuko, Nakazawa, Risa, Moriyama, Takanobu, Gellermann, Werner, Bernstein, Paul S.
Format: Article
Language:English
Subjects:
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692/700
Adult
Antioxidants
Antioxidants - administration & dosage
Ascorbic acid
Body mass index
Carotenoids
Carotenoids - analysis
Dietary Supplements
Dose-Response Relationship, Drug
Female
Healthy Volunteers
Humanities and Social Sciences
Humans
Lutein - administration & dosage
Macula Lutea - chemistry
Macula Lutea - drug effects
Macular Degeneration - prevention & control
Macular Pigment - analysis
Male
Middle Aged
multidisciplinary
Optical density
Prospective Studies
Science
Science (multidisciplinary)
Skin - drug effects
Spectroscopy
Variance analysis
Vitamin E
Zeaxanthin
Zeaxanthins - administration & dosage
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Summary:The effect of a high dose lutein/zeaxanthin supplement on macular pigment optical density (MPOD) and skin carotenoid (SC) levels in healthy subjects was investigated. This is a prospective, single-arm, open-label study. Subjects were 16 Japanese, age 26–57 years. Subjects took a supplement containing 20 mg/day of lutein, 4 mg/day of zeaxanthin, and other antioxidants (vitamin C, vitamin E, zinc, copper) for 16 weeks. MPOD levels were measured by a two-wavelength autofluorescence imaging technique. SC levels were measured by reflection spectroscopy. Total volume of MPOD within 9° eccentricity significantly increased by week 8 and continued to increase until week 16 ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-66962-2