Treatment-Resistant Depression With Catatonia Presenting as a Feature of Creutzfeldt-Jakob’s Disease

A high-functioning middle-aged successful businessman developed a rapid decline in his cognitive, behavioral, and motor abilities within one year. He was initially diagnosed with dementia by a neurologist and was then diagnosed with pseudo-dementia secondary to major depressive disorder with cataton...

Full description

Saved in:
Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2020-05, Vol.12 (5)
Main Authors: Uneib, Muhammad, Devereaux, Randolph, Rutkofsky, Ian H, Lahoti, Sourabh, Lopez, Marvin
Format: Article
Language:English
Subjects:
Case reports
Catatonia
Dementia
Disease control
Echolalia
Electroconvulsive therapy
Internal Medicine
Medical laboratories
Mental depression
Middle age
Neurology
Patients
Psychiatry
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A high-functioning middle-aged successful businessman developed a rapid decline in his cognitive, behavioral, and motor abilities within one year. He was initially diagnosed with dementia by a neurologist and was then diagnosed with pseudo-dementia secondary to major depressive disorder with catatonia by a psychiatrist who initiated treatment with Ativan. He was referred to our psychiatric facility for an evaluation to undergo electroconvulsive therapy (ECT) as a potential treatment for medically refractory depression complicated with catatonia and pseudo-dementia. The neurology team and internal medicine team were consulted by a psychiatrist for clearance to begin a course of ECT. In this process, with a coordinated effort and prompt workup and evaluation, including neurological testing, imaging, and positive cerebrospinal fluid analysis for real-time quaking inverse conversion (RT-QuIC) and 14-3-3, the patient was diagnosed with Creutzfeldt-Jakob’s disease.There are many organic causes of dementia and catatonia that should be explored in depth, especially when the clinical picture is challenging and atypical.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.8300