Development of an abbreviated symptom score for the neonatal abstinence syndrome

Objective We sought a shortened MOTHER neonatal abstinence syndrome (NAS) and Finnegan score that would retain comparable performance characteristics of the full instrument. Study design Retrospective cohort. Results In total, 124,170 MOTHER NAS scores between August 2007 and May 2016 from 775 infan...

Full description

Saved in:
Bibliographic Details
Published in:Journal of perinatology 2020-07, Vol.40 (7), p.1031-1040
Main Authors: Chervoneva, I., Adeniyi-Jones, S. C., Blanco, F., Kraft, W. K.
Format: Article
Language:English
Subjects:
692/699/375/2764
692/700/1720
Analysis
Drug therapy
Drug withdrawal
Infants
Infants (Newborn)
Medicine
Medicine & Public Health
Morphine
Narcotics
Neonatal abstinence syndrome
Neonates
Newborn babies
Pediatric Surgery
Pediatrics
Random variables
Regression analysis
Regression models
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective We sought a shortened MOTHER neonatal abstinence syndrome (NAS) and Finnegan score that would retain comparable performance characteristics of the full instrument. Study design Retrospective cohort. Results In total, 124,170 MOTHER NAS scores between August 2007 and May 2016 from 775 infants (≥36 weeks) were examined. Classification and regression tree model identified the most important subsets of the scored variables. A 9-element shortened scale yielded >90% sensitivity and specificity to predict clinical endpoints based on the full 19-element MOTHER NAS score. Conversion of the data sets to the Finnegan score, and applying the same procedure resulted in a nine-element score with similar performance characteristics. Conclusion Shortened scoring instruments were identified with the high-predictive power for clinical endpoints based on the 19-element full MOTHER NAS score. There was no substantial variation in performance for age, supporting the current practice of utilizing a single scoring tool regardless of postnatal age.
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-020-0606-4