C1 esterase inhibitor and the contact system in COVID‐19

Summary Coronavirus disease 2019 (COVID‐19) is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life‐threatening abnormalities are multifactorial. Based on the analysis of publicly available...

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Bibliographic Details
Published in:British journal of haematology 2020-08, Vol.190 (4), p.520-524
Main Authors: Thomson, Timothy M., Toscano‐Guerra, Emily, Casis, Ernesto, Paciucci, Rosanna
Format: Article
Language:English
Subjects:
complement
Complement C1 Inhibitor Protein - metabolism
contact system
Coronaviruses
COVID-19
COVID-19 - metabolism
COVID-19 - pathology
Esterase
Hematology
Humans
SARS-CoV-2 - metabolism
SARS‐CoV‐2
serpins
Severe acute respiratory syndrome
Short Reports
Vasculitis
virology
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Summary:Summary Coronavirus disease 2019 (COVID‐19) is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life‐threatening abnormalities are multifactorial. Based on the analysis of publicly available interactomes, we propose that severe acute respiratory syndrome coronavirus‐2 infection directly causes a deficiency in C1 esterase inhibitor, a pathogen‐specific mechanism that may help explain significant systemic abnormalities in patients with COVID‐19.
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.16938