A contemporary review on pathogenesis and immunity of COVID-19 infection

Emerging of the COVID-19 pandemic has raised interests in the field of biology and pathogenesis of coronaviruses; including interactions between host immune reactions specific, and viral factors. Deep knowledge about the interaction between coronaviruses and the host factors could be useful to provi...

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Bibliographic Details
Published in:Molecular biology reports 2020-07, Vol.47 (7), p.5365-5376
Main Authors: Mirzaei, Rasoul, Karampoor, Sajad, Sholeh, Mohammad, Moradi, Pouya, Ranjbar, Reza, Ghasemi, Faezeh
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Animals
Autoimmunity
Betacoronavirus - genetics
Betacoronavirus - immunology
Biomedical and Life Sciences
Bronchopulmonary infection
Coronaviridae
Coronavirus Infections - etiology
Coronavirus Infections - genetics
Coronavirus Infections - immunology
Coronavirus Infections - virology
Coronaviruses
COVID-19
Cytokines - immunology
Histology
Humans
Immune response
Immunity, Innate
Interferons - immunology
Life Sciences
Morphology
Original
Original Article
Pandemics
Pathogenesis
Pneumonia, Viral - etiology
Pneumonia, Viral - genetics
Pneumonia, Viral - immunology
Pneumonia, Viral - virology
Receptors, Coronavirus
Receptors, Virus
SARS-CoV-2
Virus Replication
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Summary:Emerging of the COVID-19 pandemic has raised interests in the field of biology and pathogenesis of coronaviruses; including interactions between host immune reactions specific, and viral factors. Deep knowledge about the interaction between coronaviruses and the host factors could be useful to provide a better support for the disease sufferers and be advantageous for managing and treatment of the lung infection caused by the virus. At this study, we reviewed the updated information on the pathogenesis of the COVID-19 and the immune responses toward it, with a special focus on structure, genetics, and viral accessory proteins, viral replication, viral receptors, the human immune reactions, cytopathic effects, and host-related factors.
ISSN:0301-4851
1573-4978
1573-4978
DOI:10.1007/s11033-020-05621-1