Lung cancer prediction in Lambert-Eaton myasthenic syndrome in a prospective cohort

To evaluate the Dutch-English Lambert-Eaton Myasthenic Syndrome (LEMS) Tumour Association Prediction (DELTA-P) score in a prospective cohort of patients with newly diagnosed LEMS to assess the clinical validity of this tool in a real-world setting. Clinical features from 87 patients with LEMS, occur...

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Published in:Scientific reports 2020-06, Vol.10 (1), p.10546-10546, Article 10546
Main Authors: Maddison, Paul, Lipka, Alexander F., Gozzard, Paul, Sadalage, Girija, Ambrose, Philip A., Lang, Bethan, Verschuuren, Jan J.
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Subjects:
692/4028
692/617
Adolescent
Adult
Aged
Aged, 80 and over
Cancer screening
Child
Early Detection of Cancer
Female
Health risk assessment
Humanities and Social Sciences
Humans
Lambert-Eaton myasthenic syndrome
Lambert-Eaton Myasthenic Syndrome - complications
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - etiology
Male
Medical screening
Middle Aged
multidisciplinary
Neuromuscular junctions
Predictions
Prospective Studies
Risk Factors
Science
Science (multidisciplinary)
Small cell lung carcinoma
Small Cell Lung Carcinoma - diagnosis
Small Cell Lung Carcinoma - etiology
Tobacco
Tumors
Young Adult
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description To evaluate the Dutch-English Lambert-Eaton Myasthenic Syndrome (LEMS) Tumour Association Prediction (DELTA-P) score in a prospective cohort of patients with newly diagnosed LEMS to assess the clinical validity of this tool in a real-world setting. Clinical features from 87 patients with LEMS, occurring within three months from disease onset, were collated to produce a DELTA-P score for each patient. Lung cancer was detected in 44/87 (51%) LEMS patients. Weight loss ≥ 5%, tobacco use at LEMS onset and age at onset ≥ 50 years were independent predictors for the development of small-cell lung cancer (SCLC) in LEMS patients in multivariable analysis. Median DELTA-P scores were significantly higher in SCLC-LEMS patients (3.5, 95% CI 3 to 4) compared to non-tumour-LEMS (2, 95% CI 1 to 2) (P 
doi_str_mv 10.1038/s41598-020-67571-9
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Clinical features from 87 patients with LEMS, occurring within three months from disease onset, were collated to produce a DELTA-P score for each patient. Lung cancer was detected in 44/87 (51%) LEMS patients. Weight loss ≥ 5%, tobacco use at LEMS onset and age at onset ≥ 50 years were independent predictors for the development of small-cell lung cancer (SCLC) in LEMS patients in multivariable analysis. Median DELTA-P scores were significantly higher in SCLC-LEMS patients (3.5, 95% CI 3 to 4) compared to non-tumour-LEMS (2, 95% CI 1 to 2) (P &lt; 0.0001). Higher DELTA-P scores increased the risk of SCLC stepwise (score 0 = 0%, 1 = 18.8%, 2 = 45%, 3 = 55.5%, 4 = 85.7%, 5 = 87.5%, 6 = 100%). The area under the curve of the receiver operating curve was 82.5% (95% CI 73.9% to 91%). The DELTA-P cancer prediction score, calculated at the time of LEMS diagnosis, is an effective tool for cancer screening in an independent, prospective study setting.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32601396</pmid><doi>10.1038/s41598-020-67571-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects 692/4028
692/617
Adolescent
Adult
Aged
Aged, 80 and over
Cancer screening
Child
Early Detection of Cancer
Female
Health risk assessment
Humanities and Social Sciences
Humans
Lambert-Eaton myasthenic syndrome
Lambert-Eaton Myasthenic Syndrome - complications
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - etiology
Male
Medical screening
Middle Aged
multidisciplinary
Neuromuscular junctions
Predictions
Prospective Studies
Risk Factors
Science
Science (multidisciplinary)
Small cell lung carcinoma
Small Cell Lung Carcinoma - diagnosis
Small Cell Lung Carcinoma - etiology
Tobacco
Tumors
Young Adult
title Lung cancer prediction in Lambert-Eaton myasthenic syndrome in a prospective cohort
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