Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders

Non-neoplastic bone marrow disorders such as non-regenerative immune-mediated anemia, pure red cell aplasia, and myelodysplastic syndrome are major causes of non-regenerative anemia in dogs. However, there has been no study on the clinical and clinicopathological features of canine non-neoplastic bo...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2020, Vol.82(6), pp.771-778
Main Authors: TANI, Akiyoshi, TOMIYASU, Hirotaka, OHMI, Aki, OHNO, Koichi, TSUJIMOTO, Hajime
Format: Article
Language:English
Subjects:
Anemia
Anemia, Hemolytic - pathology
Anemia, Hemolytic - veterinary
Animals
Aplasia
Bone marrow
Bone Marrow Diseases - drug therapy
Bone Marrow Diseases - pathology
Bone Marrow Diseases - veterinary
canine
Dog Diseases - blood
Dog Diseases - drug therapy
Dog Diseases - pathology
Dogs
Female
Genetic Predisposition to Disease
Genomes
Glucocorticoids - therapeutic use
Immunosuppressive Agents - therapeutic use
Internal Medicine
Japan
Male
Myelodysplastic syndrome
myelofibrosis
non-regenerative immune-mediated anemia
Peripheral blood
Prednisolone - therapeutic use
Retrospective Studies
Species Specificity
Thrombocytosis
Treatment Outcome
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Summary:Non-neoplastic bone marrow disorders such as non-regenerative immune-mediated anemia, pure red cell aplasia, and myelodysplastic syndrome are major causes of non-regenerative anemia in dogs. However, there has been no study on the clinical and clinicopathological features of canine non-neoplastic bone marrow disorders in Japan. Hence, we first investigated the breed disposition of non-neoplastic bone marrow disorders that induce anemia as a retrospective study and found that Miniature Dachshund (MD) was a predisposed breed. Based on this finding, we investigated the clinical and clinicopathological features of non-neoplastic bone marrow disorders in MDs as a preliminary retrospective study, and we compared them between immunosuppressive treatment-responsive and -resistant MDs. We found that treatment-resistant MDs showed thrombocytosis and increased frequencies of dysplastic features in the peripheral blood. These results indicate that bone marrow disorders in treatment-resistant MDs might manifest distinct features compared with those in treatment-sensitive MDs, and sensitivity to immunosuppressive treatments could be predicted based on thrombocytosis and dysplastic features in the peripheral blood. Further studies that examine aberrations in the genome are needed to elucidate the pathophysiology of bone marrow disorders in MDs.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.19-0439