Anti-Inflammatory Interleukin 10 Inversely Relates to Coronary Atherosclerosis in Persons With Human Immunodeficiency Virus

• Published in: The Journal of infectious diseases 2020-02, Vol.221 (4), p.510-515
• Main Authors: Fourman, Lindsay T, Saylor, Charles F, Cheru, Lediya, Fitch, Kathleen, Looby, Sara, Keller, Kiana, Robinson, Jake A, Hoffmann, Udo, Lu, Michael T, Burdo, Tricia, Lo, Janet
• Format: Article
• Language: English
• Subjects: Adult; Angiography; Anti-HIV Agents - therapeutic use; Arteriosclerosis; Atherosclerosis; Biomarkers - blood; Cardiovascular diseases; Clinical trials; Computed tomography; Computed Tomography Angiography; Coronary Artery Disease - blood; Coronary Artery Disease - complications; Coronary Artery Disease - diagnostic imaging; Cytokines; Editor's Choice; Enzyme-linked immunosorbent assay; Female; HIV; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - virology; HIV-1 - genetics; Human immunodeficiency virus; Humans; Inflammation; Inflammation - blood; Inflammation - immunology; Interleukin 10; Interleukin-10 - blood; Interleukin-10 - immunology; Major and Brief Reports; Male; Middle Aged; Plaque, Atherosclerotic - diagnostic imaging; Risk Factors; RNA, Viral - genetics
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/jiz254

Abstract Interleukin 10 (IL-10) is an anti-inflammatory cytokine that may be protective against coronary atherosclerosis. In an observational study of persons with human immunodeficiency virus (PWH) and uninfected controls, IL-10 was measured in serum samples by means of enzyme-linked immunosorbent assay, and coronary atherosclerosis was assessed using computed tomographic angiography. Among PWH, a 10-fold decrease in IL-10 was associated with a 2.6-fold increase in the odds of coronary plaque (P = .01), after controlling for traditional and nontraditional cardiovascular risk factors. IL-10 was also inversely associated with total coronary plaque (ρ = −0.19; P = .02) and noncalcified coronary plaque (ρ = −0.24; P = .004). Our findings suggest a role for IL-10 in mitigating atherosclerosis in PWH. Clinical Trials Registration. NCT00455793 Immune factors that may be atheroprotective in human immunodeficiency virus (HIV) have not been well identified. Our observational study showed an inverse association between anti-inflammatory interleukin 10 and coronary plaque, suggesting that interleukin 10 may help mitigate atherosclerosis in HIV.