Serum sphingolipids and incident diabetes in a US population with high diabetes burden: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Genetic or pharmacological inhibition of de novo sphingolipid synthases prevented diabetes in animal studies. We sought to evaluate prospective associations of serum sphingolipids with incident diabetes in a population-based cohort. We included 2010 participants of the Hispanic Community Health Stud...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2020-07, Vol.112 (1), p.57-65
Main Authors: Chen, Guo-Chong, Chai, Jin Choul, Yu, Bing, Michelotti, Gregory A, Grove, Megan L, Fretts, Amanda M, Daviglus, Martha L, Garcia-Bedoya, Olga L, Thyagarajan, Bharat, Schneiderman, Neil, Cai, Jianwen, Kaplan, Robert C, Boerwinkle, Eric, Qi, Qibin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Ceramide
Chronic illnesses
Diabetes
Diabetes mellitus
Diabetes Mellitus - blood
Diabetes Mellitus - epidemiology
Diabetes Mellitus - ethnology
Fatty acids
Female
Health risk assessment
Health risks
Hispanic Americans
Hispanic or Latino - statistics & numerical data
Humans
lipids
Male
Metabolomics
Middle Aged
Original Research Communications
Population studies
Prospective Studies
Risk analysis
Risk Factors
Sphingolipids
Sphingolipids - blood
Sphingomyelin
Triglycerides
United States - epidemiology
United States - ethnology
Young Adult
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Summary:Genetic or pharmacological inhibition of de novo sphingolipid synthases prevented diabetes in animal studies. We sought to evaluate prospective associations of serum sphingolipids with incident diabetes in a population-based cohort. We included 2010 participants of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) aged 18–74 y who were free of diabetes and other major chronic diseases at baseline (2008–2011). Metabolomic profiling of fasting serum was performed using a global, untargeted approach. A total of 43 sphingolipids were quantified and, considering subclasses and chemical structures of individual species, 6 sphingolipid scores were constructed. Diabetes status was assessed using standard procedures including blood tests. Multivariable survey Poisson regressions were applied to estimate RR and 95% CI of incident diabetes associated with individual sphingolipids or sphingolipid scores. There were 224 incident cases of diabetes identified during, on average, 6 y of follow-up. After adjustment for socioeconomic and lifestyle factors, a ceramide score (RR Q4 versus Q1 = 2.40; 95% CI: 1.24, 4.65; P-trend = 0.003) and a score of sphingomyelins with fully saturated sphingoid-fatty acid pairs (RR Q4 versus Q1 = 3.15; 95% CI: 1.75, 5.67; P-trend
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/nqaa114