The interaction between ferroptosis and lipid metabolism in cancer

Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that occur in lipid metabolism during ferroptosis and have provided intriguing insights into the interplay between ferroptosis...

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Bibliographic Details
Published in:Signal transduction and targeted therapy 2020-06, Vol.5 (1), p.108-108, Article 108
Main Authors: Li, Dingshan, Li, Yongsheng
Format: Article
Language:English
Subjects:
631/67
692/4028/67
Cancer
Cancer Research
Cell Biology
Ferroptosis
Internal Medicine
Lipids
Medicine
Medicine & Public Health
Metabolism
Oncology
Pathology
Review
Review Article
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Summary:Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that occur in lipid metabolism during ferroptosis and have provided intriguing insights into the interplay between ferroptosis and lipid metabolism in cancer. Their interaction regulates the initiation, development, metastasis, therapy resistance of cancer, as well as the tumor immunity, which offers several potential strategies for cancer treatment. This review is a brief overview of the features characterizing the interaction between ferroptosis and lipid metabolism, and highlights the significance of this interaction in cancer.
ISSN:2059-3635
2095-9907
2059-3635
DOI:10.1038/s41392-020-00216-5