Case Studies in Neuroscience: The electrophysiology of a human obsession in nucleus accumbens

Microelectrode recordings were performed during awake deep brain stimulation surgery for obsessive-compulsive disorder, revealing robust brain oscillations that were plainly visible throughout the ventral striatum. There was an elegant topological correspondence between each oscillation and the unde...

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Bibliographic Details
Published in:Journal of neurophysiology 2019-06, Vol.121 (6), p.2336-2340
Main Authors: Miller, Kai J, Prieto, Thomas, Williams, Nolan R, Halpern, Casey H
Format: Article
Language:English
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Case Studies in Neuroscience
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Summary:Microelectrode recordings were performed during awake deep brain stimulation surgery for obsessive-compulsive disorder, revealing robust brain oscillations that were plainly visible throughout the ventral striatum. There was an elegant topological correspondence between each oscillation and the underlying brain anatomy, most prominently a ~35Hz gamma-oscillation specific to the nucleus accumbens. Direct provocation of the patient's contamination obsession modulated both firing rate and gamma-oscillation amplitude within the nucleus accumbens.
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.00096.2019