Immune reaction and regulation in transplantation based on pluripotent stem cell technology

The development of pluripotent stem cell (PSC)-based technologies provides us a new therapeutic approach that generates grafts for transplantation. In order to minimize the risk of immune reaction, the banking of induced pluripotent stem cells (iPSCs) from donors with homozygous human leukocyte anti...

Full description

Saved in:
Bibliographic Details
Published in:Inflammation and Regeneration 2020-07, Vol.40 (1), p.1-12
Main Authors: Otsuka, Ryo, Wada, Haruka, Murata, Tomoki, Seino, Ken-ichiro
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Cell therapy
Cloning
Haplotypes
Immune regulation
Immunological rejection
Ligands
Lymphocytes
Pluripotent stem cell
Regulation
Review
Stem cells
Transplantation
Transplants & implants
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The development of pluripotent stem cell (PSC)-based technologies provides us a new therapeutic approach that generates grafts for transplantation. In order to minimize the risk of immune reaction, the banking of induced pluripotent stem cells (iPSCs) from donors with homozygous human leukocyte antigen (HLA) haplotype is planned in Japan. Even though pre-stocked and safety validated HLA-homozygous iPSCs are selected, immunological rejection may potentially occur because the causes of rejection are not always due to HLA mismatches. A couple of studies concerning such immunological issues have reported that genetic ablation of HLA molecules from PSC combined with gene transduction of several immunoregulatory molecules may be effective in avoiding immunological rejection. Also, our research group has recently proposed a concept that attempts to regulate recipient immune system by PSC-derived immunoregulatory cells, which results in prolonged survival of the same PSC-derived allografts. PSC-based technologies enable us to choose a new therapeutic option; however, considering its safety from an immunological point of view should be of great importance for safe clinical translation of this technology.
ISSN:1880-9693
1880-8190
DOI:10.1186/s41232-020-00125-8