Overview of Alternaria alternata Membrane Proteins

Alternaria species are mainly saprophytic fungi, but some pathotypes of Alternaria alternata infect economically important plants including cereal crops, vegetables and fruits. Specially, A . alternata generates toxins which contaminate food and feed. To date, management of A . alternata relies prim...

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Bibliographic Details
Published in:Indian journal of microbiology 2020-09, Vol.60 (3), p.269-282
Main Authors: Wang, Ruyi, Zhao, Peng, Ge, Xizhen, Tian, Pingfang
Format: Article
Language:English
Subjects:
Alternaria alternata
Biomedical and Life Sciences
Cereal crops
Data mining
Economic importance
Food contamination
Fungi
Fungicides
Life Sciences
Medical Microbiology
Membrane proteins
Membranes
Microbiology
Molecular structure
Pathogenicity
Pathogens
Pesticides
Plants (botany)
Proteins
Review
Review Article
Signal transduction
Toxins
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Summary:Alternaria species are mainly saprophytic fungi, but some pathotypes of Alternaria alternata infect economically important plants including cereal crops, vegetables and fruits. Specially, A . alternata generates toxins which contaminate food and feed. To date, management of A . alternata relies primarily on fungicides. However, the control efficacy in most cases is below expectation due to ubiquity of A . alternata and resistance to fungicides. To mitigate resistance and develop long-lasting fungicides, uncovering multiple rather than single target is a prerequisite. Membrane proteins are potential targets of fungicides owing to wide participation in myriad biochemical events especially material transport, signal transduction and pathogenicity. However, so far, little is known about the distribution and molecular structure of A. alternata membrane proteins (AAMPs). Herein we summarize AAMPs by data mining and subsequent structure prediction. We also outline the state-of-the-art research advances of AAMPs especially those closely related to pathogenicity. Overall, this review aims to portray a picture of AAMPs and provide valuable insights for future development of highly efficient fungicides towards A . alternata or beyond.
ISSN:0046-8991
0973-7715
DOI:10.1007/s12088-020-00873-8