SARS-CoV-2 does not replicate in embryonated hen's eggs or in MDCK cell lines

The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production platforms as respiratory samples are used to directly inoculate e...

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Bibliographic Details
Published in:Euro surveillance : bulletin européen sur les maladies transmissibles 2020-06, Vol.25 (25), p.10
Main Authors: Barr, Ian G, Rynehart, Cleve, Whitney, Paul, Druce, Julian
Format: Article
Language:English
Subjects:
Animals
Betacoronavirus
Cell Line
Chickens - immunology
Chickens - virology
Coronavirus - physiology
Coronavirus Infections - epidemiology
Coronavirus Infections - virology
COVID-19
Dogs
Eggs
Humans
Immunization
Influenza Vaccines - immunology
Influenza, Human - prevention & control
Madin Darby Canine Kidney Cells
Pandemics
Pneumonia, Viral
Rapid Communication
Receptors, Virus - metabolism
SARS-CoV-2
Severe Acute Respiratory Syndrome
Severe acute respiratory syndrome coronavirus 2
Studies
Vaccines
Virology
Virus Cultivation - methods
Virus Replication
Zoonoses
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Summary:The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production platforms as respiratory samples are used to directly inoculate embryonated hen's eggs and continuous cell lines that are used to isolate and produce influenza vaccines. We investigated the ability of these substrates to propagate SARS-CoV-2 and found that neither could support SARS-CoV-2 replication.
ISSN:1560-7917
1025-496X
1560-7917
DOI:10.2807/1560-7917.ES.2020.25.25.2001122