Prolonged viral shedding in a lymphoma patient with COVID-19 infection receiving convalescent plasma

Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first identified in Wuhan, China; and spread all over the world. Reverse-transcription polymerase chain reaction (RT-PCR) test for SARS-CoV-2 usually returns to negative in 20 days post-infection, but prolonged positivity has been reported up to...

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Bibliographic Details
Published in:Transfusion and apheresis science 2020-10, Vol.59 (5), p.102871-102871, Article 102871
Main Authors: Karataş, Ayşe, İnkaya, Ahmet Çağkan, Demiroğlu, Haluk, Aksu, Salih, Haziyev, Tahmaz, Çınar, Olgu Erkin, Alp, Alpaslan, Uzun, Ömrüm, Sayınalp, Nilgün, Göker, Hakan
Format: Article
Language:English
Subjects:
Autologous stem cell transplantation (ASCT)
Case Report
Convalescent plasma
COVID-19
COVID-19 - therapy
COVID-19 - virology
Health technology assessment
Humans
Immunization, Passive
Lymphoma
Lymphoma - virology
Male
Middle Aged
SARS-CoV-2
SARS-CoV-2 - physiology
Virus Shedding - physiology
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Summary:Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first identified in Wuhan, China; and spread all over the world. Reverse-transcription polymerase chain reaction (RT-PCR) test for SARS-CoV-2 usually returns to negative in 20 days post-infection, but prolonged positivity has been reported up to 63 days. A case whose viral shedding lasted 60 days is reported from China. Herein we report a patient with a history of autologous stem cell transplantation (ASCT) for lymphoma whose RT-PCR test remained positive for SARS-CoV-2 for 74 days. The prolonged RT-PCR positivity, despite convalescent plasma infusion, may suggest that the given antibodies may be ineffective in terms of viral clearance. In patients with hematological malignancies or immunosuppression, such as ASCT, may lead to prolonged viral shedding, and strict isolation is warranted for long-term SARS-CoV-2 infection control.
ISSN:1473-0502
1878-1683
1473-0502
DOI:10.1016/j.transci.2020.102871