Personalised mapping of tumour development in synchronous colorectal cancer patients

Synchronous colorectal cancers (syCRCs) are two or more primary tumours identified simultaneously in a patient. Previous studies report high inter-tumour heterogeneity between syCRCs, suggesting independent origin and different treatment response, making their management particularly challenging, wi...

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Bibliographic Details
Published in:Npj genomic medicine 2020-07, Vol.5
Main Authors: Thomas, Valentina, Cotter, Maura B., Tosetto, Miriam, Khaw, Yi Ling, Geraghty, Robert, Winter, Desmond C., Ryan, Elizabeth J., Sheahan, Kieran, Furney, Simon J.
Format: Article
Language:English
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Case Report
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Summary:Synchronous colorectal cancers (syCRCs) are two or more primary tumours identified simultaneously in a patient. Previous studies report high inter-tumour heterogeneity between syCRCs, suggesting independent origin and different treatment response, making their management particularly challenging, with no specific guidelines currently in place. Here, we performed in-depth bioinformatic analyses of genomic and transcriptomic data of a total of eleven syCRCs and one metachronous CRC collected from three patients. We found mixed microsatellite status between and within patients. Overlap of mutations between synchronous tumours was consistently low (
ISSN:2056-7944
DOI:10.1038/s41525-020-0134-3