Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

Oral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysi...

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Bibliographic Details
Published in:Journal of oncology 2020, Vol.2020 (2020), p.1-14
Main Authors: D’Angelo, Luigi, Inchingolo, Francesco, Feola, Antonia, Di Domenico, Marina, Coppola, Mario, Settembre, Giuliana, Sacco, Alessandra, Sciarra, Antonella, Romano, Antonio, Zannini, Giuseppa, Boccellino, Mariarosaria, Contaldo, M., Di Carlo, A.
Format: Article
Language:English
Subjects:
Angiogenesis
Cell division
Cell growth
Chemokines
Cytokines
Development and progression
Epigenetic inheritance
Growth factors
Homeostasis
Hormones
Hormones, Sex
Inflammation
Influence
Medical prognosis
Metastasis
Neutrophils
Oral cancer
Pathogens
Peptides
Prostate cancer
Review
Risk factors
Squamous cell carcinoma
Tumors
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Summary:Oral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysimmune and autoimmune diseases, in the oral cancerogenesis. Particularly, oral candidiasis and periodontal diseases introduce a vicious circle of nonhealing and perpetuation of the inflammatory processes, thus leading toward cancer occurrence via local and systemic inflammatory modulators and via genetic and epigenetic factors.
ISSN:1687-8450
1687-8450
DOI:10.1155/2020/9587971